Clinical Study On The Treatment Of Reflux Esophagitis(liver And Stomach Stagnation-heat Evidence)with The Addition Of San Xiang Tang

Objective:To observe the clinical efficacy of modified Sanxiang Decoction in the treatment of reflux esophagitis(liver stomach stagnation heat syndrome)and evaluate its safety,so as to provide a new idea for the clinical treatment of reflux esophagitis.Methods:72 patients with reflux esophagitis(liver and stomach stagnation heat syndrome)were randomly divided into two groups,36 cases in each group;The control group was treated with rabeprazole sodium enteric coated tablets,while the treatment group was treated with modified Sanxiang Decoction and rabeprazole sodium enteric coated tablets.The course of treatment in both groups was 8 weeks.Before and after treatment,the TCM symptom score and endoscopic esophageal mucosal grading of the two groups were recorded,and the data were statistically analyzed by spss22.0 software to compare the clinical effect of the two groups in the treatment of reflux esophagitis of liver stomach stagnation heat type.Results: A total of 72 patients were enrolled in this study,including 5 patients who fell out during the trial,and 67 patients who completed the trial,including 34 patients in the treatment group and 33 patients in the control group.Statistical analysis was conducted on the data of the 67 patients before the treatment,and the comparison of gender,age,disease course,gastroscopic esophageal grade and other data between the two groups showed a comparability of P>0.05.(1)Comparison of TCM syndrome scores: Compared with the control group,the improvement of symptoms of heartburn,acid refraction,epigastric burning,noise,hunger,irritability in the treatment group was significantly greater(P<0.05);the symptoms of epigastric burning,epigastric burning,epigastric distention in the control group were improved(P<0.05);the symptoms of epigastric burning,epigastric distention in the control group were improved(P<0.05);the symptoms of epigastric burning,epigastric distention were not significantly different between the two groups(P>0.05);(2)Effect of gastroscopy: the total effective rate of the treatment group was 88.24%;The total effective rate of the control group was 72.73%.The therapeutic effect of the treatment group was significantly higher than that of the control group(P<0.05),which was statistically significant,indicating that the improvement of esophageal mucosa under gastroscopy in the treatment group was better than that in the control group.(3)Therapeutic effect of TCM syndrome: the total effective rate of the treatment group was 91.18%;The total effective rate of the control group was 84.85%,and the curative effect of the treatment group was better than that of the control group(P<0.05),which was statistically significant.(4)Safety: no adverse reactions occurred in the treatment process in the two groups,showing good safety.Conclusion:As can be seen from the statistical results,Sanxiang decoction combined with rabeprazole in the treatment of reflux esophagitis(liver and stomach heat stasis syndrome)has better efficacy than rabeprazole in improving the esophageal mucosa under gastroscopy,and is safe,worthy of clinical promotion and application.