Association Of Plasma Lipoprotein Lipase And The LPL Gene Rs328 Polymorphism With Mild Cognitive Impairment In Chinese Patients With Type 2 Diabetes Mellitus

Background and Objective:Lipoprotein lipase(LPL)is the rate-limiting enzyme of catalyzing the hydrolysis of triglycerides and contributes to amyloid-β formation which shows promise as a pathological factor of cognitive decline in type 2 diabetes mellitus(T2DM).This study aims to investigate the pathogenetic roles of LPL and rs328 polymorphism with mild cognitive impairment(MCI)in Chinese T2 DM patients.Methods:Chinese T2 DM patients were recruited and divided into two groups according to the Montreal Cognitive Assessment score.Demographic data were collected,LPL was measured and neuropsychological test results were examined.Results:79 diabetic patients with MCI displayed significantly decreased plasma LPL levels(p=0.007)compared with health-cognition controls(n = 91).Correlation analysis showed that LPL was positively correlated with clock drawing test(r=0.158,p=0.043)and logical memory test(r=0.162,p=0.037),while lipoprotein a(r=-0.214,p=0.006)was inversely associated with LPL.Binary logistic regression analysis further revealed that LPL concentration was an independent factor of diabetic MCI(p=0.019).No remarkable differences were found among the distributions of rs328 variants between MCI patients and controls.No remarkable association was found among plasma LPL level,cognitive performances and lipid levels between genotypic subgroups.Conclusions:Decreased plasma level of LPL probably predicted early cognitive deficits,especially verbal disfluency.