Modification Of MIL,Metal Organic Framework And Study On Drug Loading And Release

Metal-organic framework materials（MOFs）is a coordination polymer developed rapidly in the past decade,because of MOFs with three-dimensional pore structure,controllable composition,adjustable size of molecules,high load,can be modified biological compatibility and convenient synthesis method,make the nanoscale MOFs the possibility of the application in the field of drug delivery.Up to now,in the treatment and diagnosis of cancer,the research of anticancer drug system that can effectively target cancer cells and has no damage to normal cells has been a difficult point in the field of cancer treatment.In order to overcome this difficulty,we studied the modification of MOFs with the advantage of easy surface modification.In this paper,the hyaluronic acid-based MIL nano MOF system was designed and synthesized,and its load and release performance on anticancer drugs was further studied.In order to improve the drug efficacy,we also designed a heparin-based MIL nano MOF system.The main contents of the thesis are as follows:1、Porous MIL-101＿NH₂（Fe）nano MOF,adamantane-modified phosphite（ADA-PA）and cyclodextrin modified hyaluronic acid（HACD）were synthesized.Then using the interaction between phosphoric acid and Fe and the non-covalent interaction between adamantane and cyclodextrin,the hyaluronic acid-based MIL-101＿NH₂（Fe）nano MOF system HACD@ADA-PA/MIL-101＿NH₂（Fe）was synthesized.2、The Load and in vitro release properties of the anticancer drug doxorubicin（DOX）were studied using the synthetic HACD@ADA-PA/MIL-101＿NH₂（Fe）nanometer system.The results confirmed that this nanometer system had a high loading rate and encapsulation rate for DOX,and the drug release rate in the weak acidic environment（pH value in cancer cells）is much higher than that in neutral condition（normal physiological pH value）so as to achieve the effective release of the anticancer drug DOX with low toxicity and high efficiency.3、The heparin-modified MIL-101＿NH₂（Fe）nanometer system Hep＿MIL-101＿NH₂（Fe）-H was synthesized by the interaction of sulfate groups in heparin with Fe in MIL-101＿NH₂（Fe）.Then the loading and release of the antibiotic penicillin sodium（PG）were studied.The result showed that this nanometer system has a good load effect on PG and can be released efficiently under both neutral and weak acid conditions,thus greatly improving the efficiency of antibiotics.