| Research Obj ective:Through clinical research,the effectiveness and safety of chaihu plus longgu muli tang were discussed to provide new ideas and methods for guiding treatment.Research Method:1.This study relies on the special project of Beijing Municipal Science and Technology Commission's capital clinical characteristics,and adopts the strict randomized controlled study method to randomly divide 64 patients with stable angina pectoris and anxiety of coronary heart disease with qi stagnation and blood stasis,heart and gallbladder stagnation and heat syndrome,into the traditional Chinese medicine treatment group and the control group.2.The treatment group was treated with chaihu plus longgu muli tang on the basis of conventional western medicine anti-angina treatment for coronary heart disease,while the control group was treated with conventional western medicine for coronary heart disease.The treatment cycle was 4 weeks.3.The observation indexes were angina pectoris curative effect,HAMA score,TCM symptom score,TCM single syndrome score and incidence of adverse reactions.4.Register the research plan before the research starts.Intentional analysis is adopted in the result statistics to ensure the objectivity and authenticity of the test results.In this study,SPSS20.0 software was used for data analysis.Research Results:1.Determination of curative effect of stable angina pectoris of coronary heart disease:The total effective rate of the treatment group(96.87%)is higher than that of the control group(87.50%),and the difference between the two groups is statistically significant.Before treatment,the weekly frequency of angina pectoris in the treatment group(8.79±1.24)was not significantly different from that in the control group(8.61±1.33)(P>0.05).After 4 weeks of treatment,the weekly attack frequency of angina pectoris in the treatment group was 0.64±1.32,and the difference was statistically significant(P<0.05).Compared with the weekly frequency of angina pectoris(2.73±1.64)in the control group after treatment,the difference was statistically significant(P<0.05).2.Improvement of anxiety:Before treatment,the Hamilton anxiety scale score(26.86±1.28)in the treatment group was not significantly different from that in the control group(27.11±1.53)(P>0.05).After 4 weeks of treatment,the Hamilton Anxiety Scale score in the treatment group was 20.12±1.87,and the difference was statistically significant(P<0.05).Compared with the Hamilton anxiety scale score of the control group after treatment(26.32±1.46),the difference was statistically significant(P<0.05).The total effective rate of the treatment group(90.63%)is higher than that of the control group(78.12%),and the difference between the two groups is statistically significant.3.Improvement of TCM symptoms:There was no significant difference in TCM syndrome score(26.96±4.15)between the treatment group and the control group(27.53±3.27)before treatment(P>0.05).After 4 weeks of treatment,the TCM syndrome scores of the two groups showed a downward trend.the TCM syndrome score of the treatment group was(13.63±3.08).the difference between the treatment group and the control group was statistically significant(p<0.05).The difference was statistically significant(P<0.05)compared with the control group's TCM syndrome score of(20.14±3.86)after treatment.The total effective rate of the treatment group(96.87%)is higher than that of the treatment group(71.88%),and the difference between the two groups is statistically significant.4.The improvement of single syndrome of traditional Chinese medicine:the two groups have improved in chest pain,chest tightness,vexation and impatience,chest and hypochondrium fullness,dizziness,insomnia and dreaminess.the treatment group is superior to the control group,and the level in the treatment group is superior to that in the 4th week,with statistical significance(P<0.05).The treatment group was superior to the control group in terms of urinary Huang Chi and constipation,with statistically significant difference(P<0.05).In terms of improving bitter taste and dry throat,the level in the treatment group at the 4th week is better than that at the 0th week(P<0.05),but there is no statistical difference between the group and the control group.In terms of tongue pulse,the t:reatment group improved somewhat,but the difference was not statistically significant(P>0.05).5.Safety and adverse reactions:There were no obvious abnormalities and damages in blood,urine,stool routine and liver and kidney functions of the two groups of subjects during the medication period.Adverse reactions:2 cases of diarrhea,1 case of nausea and 1 case of stomach discomfort occurred in the treatment group.Patients in the control group had 2 cases of nausea and 3 cases of stomach discomfort during treatment.The difference in adverse reactions between the two groups was not statistically significant.There were no serious adverse reactions in both groups during treatment.Research Conclusion:1.Compared with the control group,the treatment group can improve angina symptoms more effectively and reduce the occurrence frequency and attack frequency of angina pectoris.2.The anxiety of the treatment group is better than that of the control group,which can obviously improve the anxiety.3.The improvement rate of TCM syndrome points in the treatment group is higher than that in the control group,which can effectively improve the TCM syndrome of coronary heart disease(thoracic obstruction)combined with anxiety(depression syndrome).4.The improvement of the main syndromes of single TCM syndromes in the treatment group is better than that in the control group,which can effectively improve the symptoms of coronary heart disease(thoracic obstruction)combined with anxiety(depression syndrome).5.The incidence of adverse reactions in the treatment group is less than that in the control group,which is safer. |
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