Design Of New Optogenetic Sinusoidal Probe:Optical And Mechanical Simulation

After spending years working on Neural Probe Microtechnologies’s dimension to get smaller neural tissues invasiveness possible;we now touched the limit in term of mechanical resistance.Some new probe shape design(sinusoidal probe shape)opened new possibilities for long-term implant invasiveness and recording abilities.The goal of this paper is to continue to explore this new way of probe design and adapt it to a new technics of neural tissues stimulation:Optogenetics technology.Our works goal is to find the flexible shape that conducts well light.First,we started by studing the design feasibility aspect:shape,materials,and manufacturing.About the shape and the manufacturing aspect we mostly follow the conclusion made by a previous paper on Sinusoidal Electro Probe.This part allowed also us to find a core/cladding materials couple for our optic-guide with good flexibility proprieties,biocompatibilities and a good ratio core/cladding refraction index.We stopped our choice on the couple Parylene-C/Parylene-N for all these previous reasons.Second,we conducted optic simulations with two different methods:Beam and Ray tracing method.The results gave us an overview of all the shape parameters,which can influence the light conduction.So we concluded with a small group of shape design that conducts well along the probe.Lastly,we mechanically simulate every shape design found in the optical simulation to characterize their mechanical flexibilities.By making a comparison with Sinusoidal Electro Probe paper invasiveness conclusion,and because we kept the same global design,we could conclude about the designs possible invasiveness and recording ability of the Sinusoidal Optic Probe.Our paper concluded by gave a group of optogenetic sinusoidal probe shapes,characterize mechanically and optically,which can theoretically have good result in invasiveness and recording ability for a long-term neural implant.