The Clinical Observation Of Modified Shaofu Zhuyu Decoction In The Treatment Of Diarrhea Type Irritable Bowel Syndrome (Syndrome Of Stasis Resistance Intestinal Collaterals)

Purpose:By comparing with the study of trimebutine maleate tablets and Chinese medicine Shaofu Zhuyu Decoction,verify the clinical efficacy and safety of the classical prescription of Traditional Chinese medicine Shaofu Zhuyu Decoction,To provide the clinical evidence of Diarrhea type irritable bowel syndrome(Syndrome of stasis resistance intestinal collaterals)treatment of traditional Chinese medicine.Method:From Changchun College of Traditional Chinese Medicine Affiliated Hospital of Diarrhea type irritable bowel syndrome(Syndrome of stasis resistance intestinal collaterals)in patients with clinical diagnosis of a total of 72 bits,using a randomized method,randomly divided into 2 groups,36 cases of treatment of group,36 cases of the control group.Shaofu Zhuyu decoction on treatment group given(by the Cattail pollen,five faeces,angelica sinensis,rhizoma corydalis,myrrh,cortex cinnamomi,radix paeoniae rubra,ginger,angelica sinensis,rhizoma ligustici wallichii,fennel,rhubarb and other drugs),The course of 4 weeks.the control group given trimebutine maleate tablets,Treatment as above.Result:(1)Main symptoms of traditional Chinese medicine:the two groups by statistical comparison before and after treatment,compared with the same group before treatment bring about P~▲<0.01,P delta P~△<0.05,~▲compared with~△,bring about P<0.05).After treatment,the main symptoms of experimental group patients were significantly improved(P~▲<0.01),bring about the control the main symptoms of patients improved(delta P~△<0.05),and the curative effect of treatment group is more better than the control group.(2)Syndrome total curative effect evaluation:two groups by statistical comparison before and after the treatment,treatment group 30 cases,cure,effective,invalid respectively 8 cases,11 cases,8 cases,3cases,the markedly effective rate was 63.33%,total effective rate was 90.00%;In the control group 30 cases,cure,effective,invalid respectively 4 cases,8 cases,7 cases,11 cases,the markedly effective rate was 40.00%,total effective rate was 63.33%.The rank and inspection,that is statistically significant difference between the treatment group and control group(P<0.01).The overall clinical efficacy of treatment group is better than that of control group.(3)Symptoms integral evaluation:two groups by statistical comparison before and after the treatment,treatment group 30 cases,the symptoms score before treatment was 21.28±3.18;In the control group 30 cases symptoms score was 20.79±3.45 before treatment.The rank and inspection,the treatment group and control group no difference between the before treatment.Treatment group 30 cases,the symptoms score after treatment was 9.35±3.54;In the control group 30 cases symptoms score was 15.4±3.35 after treatment.By the rank and inspection,the treatment group after treatment and the control group after treatment compared with significant statistical difference(P<0.01).The overall clinical efficacy of treatment group is better than that of control group.(4)IBS-SSS,HAD change:two groups by statistical comparison before and after the treatment,treatment group 30 cases,the treatment of irritable bowel syndrome severity scale before the IBS-SSS yudhoyono,hospital anxiety and depression scale scores were 51.57±7.45,51.40±6.08 mm;In the control group 30 cases before treatment severity scale IBS–SSS,hospital anxiety and depression scale HAD score of 51.57±7.58,7.58±6.24 respectively.The rank and inspection,the treatment group and control group no difference between the before treatment.Treatment group 30 cases,after treatment severity scale IBS-SSS,hospital anxiety and depression scale HAD scores were36.73±6.25,37.57±7.10 mm;In the control group 30 cases after treatment severity scale IBS-SSS,hospital anxiety and depression scale HAD scores were 37.50±6.03,38.57±6.10mm.By the rank and inspection,the treatment group after treatment and the control group after treatment compared with significant statistical difference(P<0.01).Treatment group can obviously improve the clinical symptoms such as anxiety,depression,control group also has the effect,but the experimental group curative effect is bigger.Conclusion:From the above data are obtained,To disperse blood stasis and dredge collateral,regulating ying relieving pain method and"purgative method"of traditional Chinese medicine as the basic treatment,Using shaofu zhuyu decoction for treatment of Diarrhea type irritable bowel syndrome(Syndrome of stasis resistance intestinal collaterals)curative effect significantly,can significantly improve the patient’s clinical symptoms and TCM syndrome manifestations.On the clinical treatment,shaofu zhuyu decoction also more safety.