| Objective Through the analysis of the syndrome differentiation of traditional Chinese medicine concludes that syndrome type distribution of Helicobacter pylori-related chronic gastritis; To select the most common witness syndrome: spleen-stomach damp-heat syndrome and observe the effection of fuzheng qingyou decoction with the quadri-combination therapy to it.Methods This study consists of two parts:1. Select 510 patients who are come from the cadres digestive system department of the Anhui province Chinese medicine hospital and from September,2010 to September,2015 and dignosed Helicobcter pylori-related chronic gastritis. Analysis all of the patients’ incidence, clinical symptoms, tongue coating, pulse conditionwith statistics, then sums up the distribution law.2.Select 60 patients who are come from the cadres digestive system department of the Anhui province Chinese medicine hospital and from October,2014 to October,2015 and were dignosed Helicobcter pylori-related chronic gastritis with spleen-stomach damp-heat syndrome. The patients were split into two groups In a random number table method.One named treatment group(fuzhengqingyou decoction, levofloxacin,clarithromycin,esomeprazole, colloidal bismuth pectin),and another is control group(levofloxacin, clarithromycin,esomeprazole, colloidal bismuth pectin).Every group have 30 patients and were cured by 14 days. Were observed the changes before and after treatment in the two groups of there clinical symptoms, syndrome integral,C14 breath test results, gastroscope and pathology, rapid urease test, the change of liver and kidney functions and so on.Results1. In the investigation of 510 cases, 283 cases of women(55.49%); Men 227 cases,accounting for 44.51%. Ratio: 1 to 1. 25, the statistical analysis of Hp infection in termsof gender has no statistical significance(P>0.05). For all ages, found that the distribution of 44-59, most middle-aged people sick, accounted for 41.37%; Young patients, 18 to 44, second, accounting for 36.86%; 60-89 of 109 cases of elderly patients(21.37%); Less than young patients at least 18 years old, only a few. From the perspective of the patient’s illness age distribution, the incidence of patients associated with age. In the investigation, summed up the patients’ different clinical symptoms and pulse condition coating on the tongue,the most common clinical symptoms as the stomch distension account for 91.37%,followed by the diagnosis stomach pain(76.27%),acid reflux and heartburn(73.52%), bitter taste and bad smell in the mouth account for61.17%, anorexia account for 57.45%, etc.; Tongue and pulse condition are give priority to red tongue, yellow greasy moss and pulse number, these are in accordance with the clinical manifestations of the spleen-stomach damp-heat syndrome. Classification classified found the spleen and stomach wet heat syndrome in 210 cases, accounted for41.18%; Liver and stomach qi stagnation is 93 cases, accounting for 18.24%; Liver stomach heat stagnation is 86 cases, accounting for 16.86%; deficiency of spleen and stomach is 77 cases, accounting for 15.10%; Stomach Yin deficiency type 37 cases,accounting for 7.25%; stomach blood stagnation type is 7 cases, accounting for 1.37%.On the constituent ratio of it, the most is spleen and stomach wet heat syndrome. From the Hp correlation gastritis classification of syndrome types of TCM and western medicine gastritis, spleen and stomach wet heat type, liver stomach heat stagnation type,Liver and stomach qi stagnation type in the majority with chronic non-atrophic gastritis person, each accounted for 66.19%, 66.67%, 63.95%; deficiency of spleen and stomach type,stomach Yin deficiency type and stomach blood stagnation type in mojor in chronic atrophic accounted for 55.84%, 86.49%, 100% respectively.Comparison in the card type gender group, there was no statistically significant difference, based on the classification of the correlation between chronic gastritis has nothing to do with gender,men and women all can get sick. From age group comparison, difference is statistically significant, the spleen and stomach wet heat syndrome in the majority with middle-aged,accounted for 47.14%; Also in the majority with middle-aged Liver stomach heat stagnation syndrome, accounted for 47.3%; Liver and stomach qi stagnation syndrome in the majority with young people, accounting for 46.51%, deficiency of spleen and stomach syndrome,stomach Yin deficiency syndrome and stomach blood stagnation syndrome are in the majority in the elderly,account for 44.16%, 45.95% and 71.43%,respectively.2. Fuzheng Qingyou decoction combined with western medicine treatment of helicobacter pylori gastritis symptom curative effect than the control group obviously.Observe the gastroscope integral,there have statistically significant differences before and after the treatment, and the obvious of patients with CSG lower than the CAG patients.Pathological compare two groups to eliminate inflammation observation level difference is statistically significant. Inflammation pathological observation found that treatment group compared with control group in degree of pathological tissue inflammation to eliminate differences statistically significant. In addition by chi-square test, the difference between the before and after treatment with chronic atrophic gastritis and chronic superficial gastritis comparison were statistically significant, in combination with the number of cases in the table, the CSG’s effectiveness treatment group is 93.75%, the CAG is 55.85%; CSG efficient in control group is 68.75%, the CAG effectiveness is 50%, it is the clinical curative effect of the CAG owe in CSG.Helicobacter pylori eradication rates found the Hp positive rate of treatment group was6.7%, the control group in the Hp positive rate was 26.67%, the treatment group is lower than the control group(P<0.05). Activity before and after treatment comparison::the treatment group before and after treatment of 14 c- UBT numerical comparison differences were significant(P<0.01), and compare differences between the two groups after treatment has significant meaning(P>0.05). Security comparison:Chinese medicine treatment group does not appear reaction, the control group using quadruple therapy to treat patients with decreased appetite in 2 cases, diarrhea in 2cases, accounting for 13.33% of the total number of cases, Considering the lesserdegree, alleviate by oneself after die and continue to the end of the course. After treatment, there were not found obvious abnormity with review of blood routine and urine, dung routine, liver and kidney function, electrocardiogram in two groups.The occurrence of adverse reactions to the two groups was statistically significant(P <0.05), and Chinese medicine group is more security than west medcine.Conclusion1.There are many traditional Chinese medicine syndrome types such as spleen and stomach wet heat syndrome, Liver and stomach qi stagnation syndrome, Liver stomach heat stagnation syndrome, deficiency of spleen and stomach syndrome, Stomach Yin deficiency syndrome and stomach blood stagnation in Helicobacter pylori-related chronic gastritis.The most type is spleen and stomach wet heat syndrome. Helicobacter pylori-related chronic gastritis has nothing to do with gender, but have relationship with age.The middle-aged is the largest on age distribution. The traditional Chinese medicine syndrome distribution of Helicobacter pylori-related chronic gastritis has nothing to do with gender, but associated with age, the more age,the more account for of deficiency of spleen and stomach syndrome, Stomach Yin deficiency syndrome and stomach blood stagnation. The traditional Chinese medicine syndrome distribution of Helicobacter pylori-related chronic gastritis associated with gastritis type, deficiency of spleen and stomach syndrome, Stomach Yin deficiency syndrome and stomach blood stagnation offen can be see in chronic atrophic gastritis; spleen and stomach wet heat syndrome, Liver and stomach qi stagnation syndrome, Liver stomach heat stagnation syndrome are most occurred in chronic non-atrophic gastritis.2. Fuzheng Qingyou decoction combined quadruple therapy can eliminate patients of spleen and stomach wet heat syndrome of Helicobacter pylori-related chronic gastritis whose clinical symptoms, can improve the Hp eradicate rate, improve patients effection under gastroscope and histological inflammation;The ability of improve histological inflammation of Fuzheng Qingyou decoction combined quadruple therapy, chronic non-atrophic gastritis is better than that of chronic atrophic gastritis; Application ofFuzheng Qingyou decoction to assist treatment can reduce adverse reaction of patients. |
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