Clinical Study On Treating Pseudobulbar Palsy Of Qi-dificiency And Obstruction Of Blood Stasis-wind-phlegm Of Ischemic Stroke With Adjustment Of Shun Yan Fang

Background:Pseudobulbar palsy is the disease of pons and the parts above the pons,cause motor neuron or corticobulbar tract damage in the bilateral cerebral cortex,it is a group of diseases which mainly appear in a hoarse voice, drinking cough,dysphagia, the main cause of it is cerebrovascular disease、inflammatory、demyelinating disease、degeneration, etc, in which cerebral.infarction is the main reason. The treatment of western medicine to PBP patients of acute stage of cerebral infarction is pay great attention to the treatment of primary disease, In addition to reduce regional cerebral edema, nutrition the brain cells, stable vital signs and symptomatic and supportive therapy, it is lack of effective methods, and lack of effective potent drugs, to rely on the nasal feeding and fluids to sustain life, to be mushy or sticky foods on the diet, supplemented by the timing stimulate the muscles of the throat, training in patients with physical therapy such as lip-sync, slow graded swallowing rehabilitation and so on, or indwelling nasogastric tube to improve the symptom of cough when swallowing and reduce the incidence of aspiration pneumonia. Chinese medicine treatment of cerebral infarction after PBP has a good effect, it is significantly improved the clinical symptoms of patients of PBP, and the long-term effect is significant, less side effects, and worthy of further study.Object ive:With a randomly Comparison observation on the curative effective about treating pseudobulbar palsy of qi-dificiency and obstruction of blood stasis-wind-phlegm of ischemic stroke with adjustment of shun yan fang. Methods:Choice80neurologic in patient department patients or in out-patient patients who have fertility requirements in our hospital in line with diagnosis of pseudobulbar palsy after cerebral infarction in Western medicine and in line with diagnosis of qi-dificiency and obstruction of blood stasis-wind-phlegm of ischemic stroke. Using random numbers were randomly divided into shun yan fang group with41patients and control group with39patients. Are all given conventional cerebral infarction and swallowing function rehabilitation training on the clinical(reference to the "neurology" of the sixth edition and the "stroke rehabilitation technology" of the first edition), asked the patients to life regularly, improve mood, and active or passive functional exercise, according to the condition of patients given anti-platelet aggregation,and the basic treatment such as improve of the cerebral circulation,nutrition the nerve cells and so an, medicinal Xue Shuantong300mg, brain protein hydrolyzate120mg intravenous infusion,A aspirin100mg orally. In accordance with the condition of patients give some basic treatment to hypertension, diabetes, heart disease.28d for a course of treatment. Shun yan fang group on the basis theatment of the control group, plus the shun yan fang recipe decoction oral qd, keeping observation on the improvement of situation such as Chinese medicine symptom score、PBP Shih score、endothelin (ET)、calcitonin gene-related peptide (CGRP). Explore the clinical efficacy of shun yan fang to PBP of qi-dificiency and obstruction of blood stasis-wind-phlegm of apoplexy endocrine.Results:1、Improvement in symptoms related to traditional Chinese medicine of two groups of patients:TCM symptom score after treatment, after t-test, there was significantly different (p＜0.05), Good improvement rate and total effective rate according to TCM symptom score comparison, after x2-test, p＜0.05, the shun yan fang group was better than the control group.2、Improvement in symptoms related to PBP Shih score of two groups of patients: PBP Shih score after treatment, after t-test, there was significantly different (p<0.05), Good improvement rate and total effective rate according to PBP Shih score, after χ2-test, p<0.05, the shun yan fang group was better than the control group.3、Improvement of ET targets of two groups of patients:after t-test, there was no significant difference and no statistical significance(p>0.05)between the shun yan fang group and the control group for improving the ET targets.4、Improvement of CGRP targets of two groups of patients:after t-test, there was significantly different (p<0.05), and the shun yan fang group was better than the control group.Conclusion:The western medicine is lack of effective methods and lack of effective potent drugs to pseudobulbar palsy of apoplexy. The majority of patients with clinical symptoms such as swallowing disorders did not improve, the quality of life is low. after observing, the results show that shun yan fang indeed can improve patient chinese medicine clinical symptoms and aphetite disorder, is worthy of further study.