Preparation, Characterization And Sustained-Release Of Antibiotic Drugs Intercalated ZN-AL Hydrotalcite

The layered double hydroxides (LDHs) drug molecules container of antibiotic drugs (Cefepime) and antihist amine drugs (Kitotifen fumarate, KF) were intercalated, for the purpose of reducing some poisonous side effect to human body and decreasing the times of taking medicine to increase medication compliance of patients.The phase structure, composition, supramolecular structure, and thermal property were studied via XRD, FT-IR, ICP-AES, TG-DTA measurement. The structure and composition of LDHs on drug release behavior in vitro and the effect of thermal stability and the relationship between each other were studied and analyzed in details. According to the results of XRD, the as-synthesized samples conform to a typical LDHs layered materials with good crystal shape of intercalated materials. The layer spacing of Cefepime LDHs and KF-LDHs is2.18nm,0.82nm respectively. In addition, a model of the surpramolecular structure to describe the structure of this material was proposed. Theoretical simulation of three-dimensional molecular size suggested that the cefepime and kitotifen fumarate guests were arranged along the long axis orientation with certain angle in the layers. TG-DTA analysis showed that the thermal stability of the material are also good. It’s difficult for the materials to occur thermal decomposition at room temperature. Finally, the in vitro release behavior characteristics and influence the release behavior of internal and external factors were systematic studied in this Dissertation. Cefepime-LDHs and KF-LDHs with obviously sustained-release effect, which release relatively quick initialy, then gradually slow. Cefepime-LDHs and KF-LDHs behavior consistent with Higuchi equation described by the diffusion mechanism. Due to the former layer between Cefepime has stronger interaction between subject and object. Series of Cefepime-LDHs is markedly lower than that of KF-LDHs. In addition, for the interaction between subject and object, the thermal stability of the interlayer anion increased significantly, which results in the decrease of Cefepime anionic conjugate effect and thermal stability.According to release kinetics study of LDHs drug release behavior fit the Fick diffusion mechanism.