Effect Of Forced Swimming Stress And Anti-Stress Medicine On The Rat Behavior And Phosphorylated ERK1/2 Level In The Rat Brain

Negative psychological stress is one of the most important factors resulting of mental disorder such as depression.To investigate the mechanism of central nervous system that how negative psychological stress result of the disease and the biological effect of anti-stress medicine is important for the prevention and cure of stress relevant mental disorder.However,it is not very clear for the central circuits involved in psychological stress and the mechanisms of the anti-stress medicine,which is the key point in bio-medicine to be solved.Rat forced swimming test(FST) is an animal model of anti-negative psychogical stress which is usually used for studying depressive disorder.And now it is widely used for anti-depression medicine selection. Rats when forced to swim in a cylinder from which they cannot escape will, after an initial period of vigorous activity, adopt a characteristic immobile posture which can be readily identified as depressive behavior. The generation of this phenomenon is close to the mechanisms of negative psychological stress result of the disease Most of antidepressant can reduce the duration of immobility in the model, which is significantly correlated to the drug action in the clinic.Extracellular signal regulated kinase 1/2(ERK1/2), an important signal molecule, is important in CNS when stress induce the activity in the brain. Phosphorylated-ERK1/2, the active form, is a new marker indicating neuronal...