A Study On Catalytic Carbonylation Synthesis Of α-naphthylacetic Acid From The 1-naphthylmethyl Chloride

α-Naphthylacetic acid is one of the most important fine chemicals. It is a modifying agent which is widely used to adjust plant's growing. The chemically pureα-naphthylacetic acid is an import intermediate in medicinal synthesis.The traditional methods of synthesizingα-naphthylacetic acid have some shortages such as low yield, long time for reaction, pollution to the environment, and so on. Aiming at these, a novel method for preparingα-naphthylacetic acid from the carbonylation of 1-naphthylmethyl chloride has been researched.The effects of the reaction conditions, such as the n(CoCl2)/n(Kpyca), CO pressure, solvents and the reaction time have been studied. The carbonylation mechanism about this reaction is discussed. At the same time, it has been groped that CoCl₂/Kpyca supported on the functional silicon. The main research contents are followed: (1) Synthesis ofα-naphthylacetic acid from carbonylation of 1-naphthylmethylchloride by CoCl₂/KPyca catalyze system is studied. Optimal reaction conditions are established through experiments. Under the conditions of c(CoCl₂)=8.3×10^-4mol/l, c(KPyca)=3.3×10^-3 mol/l, n(NaOH)/n(1-naphthylmethyl chloride)=1.5, V(DO)/V(H₂O)=5,θ=333K, p=1.8Mpa, and t=6h, the yield ofα-naphthylacetic acid is 53.2%. The mechanism of the catalytic reaction has all been discussed.(2) The catalysis performance of the catalysis systems which are composed of the other ligands and cobaltous chloride in the carbonylation of 1-naphthylmethyl chloride is studied .When the ligand differs, the yield and selectivity for NAA are differents.(3) The grafting method CoCl₂/potassium pyridine-2-carboxylate to the functional silicon has been researched initially. Using this catalyst, the yield of NAA is 51.6%, and it has still catalytic activity when it was recovered for 8 times.(4) Chemical structures of the products has been characterized.