Study On The Preparation Of Compounded Microcapsules Containing Curcumin And Piperine

Compounded Microcapsule is a new compound Chinese medicine, which consists of Curcumin and Piperine. Pharmacodynamoics studies of previous period indicate that it can reduce blood fat and protect artery from atherosclerosis. It has favorable results on the prevention and therapy of atherosclerosis diseases. The dosage form of drug was chosen as microcapsule for the demand of clinic, the function and treatment as well as the characters of component of the herbs. The thesis presented here focuses mainly on the Preparation and Quality Standard of Sodium Alginate-Chitosan Microcapsules Containing Curcumin and Piperine, which may be divided into four parts: review, preparation of Sodium Alginate-Chitosan Microcapsules using Curcumin as model drug, quality evaluation, preparation and evaluation in vitro of microcapsules containing curcumin and piperine.Part one: ReviewThe advanced progresses of new drug preparation of traditional Chinese medicine, especially for controlled release microcapsules are described, including the carrier materials, preparation methods, release characteristics of the sustained release microcapsules, which, of course, may be regarded as a basis for our succeeding research.Part two: Preparation of the compounded microcapsulesCoating material is made of Sodium Alginate and Chitosan which are natural macromolecule materials. natural macromolecule material is usually nontoxic, biocompatible and biodegradable. Because sodium alginate and chitosan are low-cost, easily-prepared and can be taken orally, it can be used to make the membrane material of sustained-release medicine. The property of microcapsules made by chitosan and sodium alginate is better than the single one.we chose curcumin as a model drug to optimize the preparation technique. We investigated the influences of different factors on the drug loading (DL) and the encapsulation efficiency (EE), including concentration of sodium alginate, chitosan, calcium chloride, and the PH. The morphology of each formulation was also observed. The optimal condition is, sodium alginate, chitosan, calcium chloride at a concentration of 2%; 0．3%, 2% (w/v); the PH is 3．5．Part three: Quality evaluation of the compounded microcapsulesIn this part, the morphology, particle size and distribution, the DL and EE, release profile of the compounded microcapsules containing Curcumin and Piperine were evaluated. After microcapsules digested with 0．05mol/L sodium citrate-enthanol ( 80:20 ) , curcumin and Piperine in Microcapsules was determined with HPLC. The average DL of the compounded microcapsules is 25．96% and 1．32%, respectively. The shape of microcapsules was investigated with electron microscope, The results showed that the microcapsules are almost spherical with smooth surface. The release of the curcumin from the compounded microcapsules may follow Higuchi equation.