Synthesis And Antibacterial Activity Of Some Ferrocenyl Thiosemicarbazones And Their Complexes With Transition Metals

1-acetyl-1'-heptylferrocenylthiosemicarbazone(abbreviated as AHFTSC) and1-acetyl-1'-bromoferrocenylthiosemicarbazone (ABFTSC) have been synthesized.We have also prepared their ten complexes with transition metals [Co(â…¡), Ni(â…¡),Cu(â…¡), Zn(â…¡) and Cd(â…¡)]. These compounds were characterized by IR and ¹H NMRspectroscopy, thermal(DTA-TG) analysis, and elemental analysis.Element analysis has proven that the general formula of these complexes is asfollow: [RFcC(CH₃)NNHCSNH₂]₂·M·xH₂O(R=-C₇H₁₅ or Br, M=Co, Ni, Cu,Zn,Cd, x=0～2). The AHFTSC ligand coordinates through sulfur and nitrogen(N¹)atoms, and the ABFTSC ligand coordinates with Co(â…¡) and Cd(â…¡) in the same way,these complexes are formed by five-membered ring chelating coordination. On theother hand, the ABFTSC ligand coordinates with Ni(â…¡),Cu(â…¡) and Zn(â…¡) throughsulfur and nitrogen(N²) atoms, forming five-membered ring. Tests of antibacterialactivity showed that two ligands and their complexes all had inhibitory actionsagainst G(+)Staphylococcus aureus and G(-)Escherichia coli. And the inhibitoryactions against G(+)Staphylococcus aureus are better than G(-)Escherichia coli.