Studies On The Regionselective And Stereoselective Synthesis Of Some Naturally Occurring Lignans

This thesis aims at the studies on the regionslective and stereoselective synthesis of naturally occurring lignans. The thesis consists of the following three parts.Chapter 1. Recent Developments in the Asymmetric Synthesis of Lignan CompoundsThe recent developments in the asymmetric aynthesis of lignan compounds in the world were reviewed according classification of lignans. Some new reagents, new reactions and new methods applied in lignans synthesis were introduced emphatically.Chapter 2. Studies on the Regionslective and Stereoselective Synthesis of Some Naturally Occurring Lignan CompoundsBy asymmetry inducement a novel efficient approach to two types of lignans, diarylbutanes, aryldihydronaphthalenes, is developed ,which is based on the regionselective oxidative coupling reaction and reversible Friedel-Crafts reaction.Chapter 3. First Total Synthsis of Cannabisin GWe successfully construct the molecule skeleton of Cannabisin G from p-cresol through bromize, substituent, Friedel-Crafts alkylation, Wittig reaction, oxidative coupling. The kye steps involve regionselective oxidative coupling reaction and reversible Friedel-Crafts reaction.