Study Of Synthesis And Fungicidal Activity Of 1,3,4-oxadiazole And Quinazoline Derivative

Fungicide is one of the important parts of the pestisides,which is used to act on the crops themselves directly and controls their growth on people's will.We have introduced 1,3,4-oxadiazole,acylthioureas and quinazoline into the compounds by bioisosterism principles and substructure link way and synthesized thirty four new compounds ,in search of some new ones with fungicidal activities.By consulting concerned literatures,we reviewed comprehensively the development of fungicide and their bactericidal mechanism and the biological activity of 1,3,4-oxadiazole,acylthioureas and quinazoline.IR, MS, ¹HNMR and the elemental analysis confirm their structures,their physical-chemical properties and spectrum datas were systematically investigated.The reaction conditions had been discussed and analysized.The main structures of the target compounds were as follows: ( â…  ) N-(1,3,4-oxadiazol-2-yl)-N'-p-methoxylphenoxyacylthioureasAr=Ph(a); 4-CH₃Ph(b); 3-CH₃Ph(c); 4-CH₃OPh(d); 4-PhCH₂OPh(e); 4-NO₂Ph(f); 3-NO₂Ph(g); 4-ClPh(h); 2-ClPh(i); 2,4-Cl₂Ph(j)(â…¡) N-(1,3,4-oxadiazol-2-yl)-N'-p-BromophenoxyacylthioureasAr=Ph(a); 4-CH₃Ph(b); 3-CH₃Ph(c); 4-CH₃OPh(d); 4-PhCH₂OPh(e); 4-NO₂Ph(f); 3-NO₂Ph(g); 4-ClPh(h); 2-ClPh(i); 2,4-Cl₂Ph(j)(â…¢)4- substituted benzoyl...