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Research On Novel Structural Fiber-Optic Sensors Based On Surface Plasmon Resonance And Their Biochemical Applications

Posted on:2018-09-26Degree:DoctorType:Dissertation
Country:ChinaCandidate:Y Z ChenFull Text:PDF
GTID:1318330536955914Subject:Optical Engineering
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Fiber-optic sensors based on surface plasmon resonance(SPR)not only have the advantages of the fiber-optic sensor like small volume,low energy consumption,rapid detection,anti-electromagnetic interference and real-time online detection;but also have the characteristics of SPR detection technology such as efficient,sensitive,label-free detection,dynamic detection and minimal sample consumption.The fiber-optic SPR sensor has become a research hotspot in the field of biochemical sensing.In this thesis,various types of novel structural fiber-optic SPR sensors are studied theoretically and experimentally,and the applications of fiber-optic SPR sensors in biochemistry are also studied.The main research work and achievements are as follows:1.A fiber-optic SPR sensor model with a non-uniform sensing layer is first proposed.We use this model to study the impact of incident light modes and sensing layer non-uniformities on the sensor performances.Results show that the higher order incident light mode increases the sensitivity,but worsens the quality factor.In the case of a non-uniform sensing layer,the length of the sensing region has an obvious effect on the sensing performances.2.A fiber-optic SPR sensor is fabricated and applied to immunoassay.We modify the sensor surface with a biomolecule specific membrane and use the modified sensor to detect the specific and nonspecific molecules.The experimental results show that the sensor has an obvious response to the specific molecule,and it has no reaction to the nonspecific molecule.The fiber-optic SPR sensor combined with specific membrane can be used in immunological detection.3.A novel semi-cylindrical fiber-optic SPR sensor is fabricated and applied to the concentration detection of chemical solution.Compared with the traditional sensor,the fabrication of our sensor is more simple and convenient,while their sensitivities are almost the same.In the detection of various solutions,our sensor shows different sensitivities and has an ultra-high sensitivity in the albumin detection,which is obtained to be 50.58 nm/%.4.A novel D-shaped photonic crystal fiber SPR sensor,which is still in the stage oftheoretical research at home and abroad,is experimentally realized.The proposed sensor can be used in wavelength and intensity interrogations simultaneously.By combining the two interrogation methods,we present a two-dimension(2D)interrogation method to improve the resolution.As a new interrogation method,the 2D resolution is determined to be 6.53 10-5RIU,which is higher than those of the wavelength and intensity interrogations.5.A liquid-core fiber-optic SPR sensor with an adjustable nano-porous silica cladding is first presented.By adjusting the refractive index of the nano-porous silica cladding,the sensor can be used in different refractive index detection ranges.A low refractive index interval of1.331.34 and a high refractive index interval of 1.421.44 are taken as examples to be investigated.Results show that our sensor works well in these two intervals by using appropriate nano-porous silica claddings.In addition,the sensing performances and the working wavelengths can be adjusted to meet different working requirements by changing the refractive index of the nano-porous silica cladding.
Keywords/Search Tags:fiber-optic SPR sensor, specific detection, D-shaped photonic crystal fiber, adjustable refractive index detection range
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