The Relationship Between GBS Infection And Miscarriage During Mid-pregnancy And The Effect Of Intervention On Pregnancy Outcome

Objective:To explore the colonization of GBS(group B streptococcus)infection in the second trimester of pregnancy and its correlation with abortion,as well as the impact of intervention on pregnancy outcome.To advance the screening of GBS infection and to achieve the aim of eugenics,a theoretical foundation must be established to enable early intervention and precise treatment,thus reducing the likelihood of adverse pregnancy outcomes.Methods:A total of 1541 pregnant women in the second trimester(14～28 weeks of pregnancy)were screened for GBS,and 228 pregnant women with positive GBS tests were selected as the research group,and 54 cases received oral antibiotic therapy(antibiotic group)and96 cases received oral probiotic treatment B(probiotic group)according to their wishes,and 78 cases were not treated with medication in group C(no intervention group).In the same period,300 pregnant women with negative GBS test were randomly used as the control group D(control group).Group A was given oral amoxicillin intervention,Group B was given oral Bifidobacterium triple viable capsule(Pefican)intervention,and Group C was given no intervention.The incidence of threatened miscarriage and miscarriage in the four groups were observed and compared,and the negative rate of GBS in the three groups was retested after 5 weeks.All participants were retested for GBS at 35 to 37weeks’ gestation and followed up on pregnancy outcomes.Results:1.There was no significant difference in pregnancy history and age between the study cohort and the control group(P>0.05).2.The positive rate of GBS in the second trimester was 14.8%.3.The incidence rates of threatened miscarriage and miscarriage in the four groups were3.7%,31.3%,38.5%,and 5%,respectively,with statistical differences(P<0.05).The results of multiple comparisons showed that the incidence of miscarriage in Group A(antibiotic group)was 3.7% lower than that in Group B(probiotics group),which was 31.3%,and Group C(non intervention group),which was 38.5%.The differences were statistically significant(P<0.05);The incidence of miscarriage related events in Group B(probiotics group)was 31.3%,while in Group C(non intervention group),the incidence of miscarriage related events was 38.5%.Both groups were higher than Group D(control group)by 5%,and the difference was statistically significant(P<0.05);The incidence of miscarriage related events in Group A(antibiotic group)was 3.7% lower than that in Group D(control group)by5%,with no statistically significant difference(P>0.05).4.Different interventions were given to pregnant women in Group A and Group B who were positive for GBS,and the negative conversion rate of the three groups of pregnant women who were positive for GBS showed significant changes after a5-week follow-up.The negative conversion rate of 14.8% in Group A(antibiotic group)was more prominent than 2.7% in Group C(non intervention group),and the difference was statistically significant(P<0.05).In addition,the negative conversion rate of 4.6% in Group B(probiotics group)was also higher than 2.7% in Group C(non intervention group),but the difference was not statistically significant(P>0.05).5.After excluding patients with mid pregnancy miscarriage,all pregnant women should be re examined for GBS between 35-37 weeks of pregnancy.201 continuously positive patients were assigned to the study group,and 292 negative patients were assigned to the control group.The incidence of fetal distress,premature delivery,premature rupture of membranes,chorioamnionitis,and Neonatal infection were different between the two groups(P<0.05).The comparison results between each group showed that the incidence of fetal distress in the study group was 18.9%,which was significantly higher than that in the control group by 7.2%,with a statistically significant difference(P<0.05);The incidence of premature birth in the study group was 14.4% higher than that in the control group,which was 7.9%,with a statistically significant difference(P<0.05);The incidence of premature rupture of membranes in the study group was 31.3% higher than that in the control group,which was 9.9%,with a statistically significant difference(P<0.05);The incidence of chorioamnionitis in the study group was 13.9% higher than that in the control group,which was 7.2%,with a statistically significant difference(P<0.05);The Neonatal infection rate in the study group was 16.9% higher than that in the control group(6.2%),with a statistically significant difference(P<0.05).Conclusion:1.GBS infection can increase the incidence of threatened abortion and abortion,and increase the incidence of adverse pregnancy outcomes.2.Antibiotics administered early on can heighten the occurrence of GBS,diminish the likelihood of abortion and its aftermath,and ameliorate the unfavorable pregnancy outcome.3.Probiotic intervention may has no obvious effect on GBS negative.