Analysis Of Risk Factors For Psoriasis Associated With Diabetes And Study On The Medication Rules Of Traditional Chinese Medicine In The Treatment Of This Diseas

Purpose:To investigate the clinical risk factors of psoriasis with diabetes,and to analyze the medication pattern of Chinese medicine for the treatment of this disease by using data mining method,so as to provide a basis for early detection and early intervention of psoriasis patients with diabetes and to provide reference for the prescription of Chinese medicine for this disease.Material and method:426 patients with psoriasis who were hospitalized in the Department of Dermatology of our hospital from January 2017 to December 2022 were taken as study subjects by logging in to the electronic medical record system of the Affiliated Hospital of Liaoning University of Chinese Medicine and were divided into two groups:psoriasis with diabetes group and psoriasis without diabetes group according to whether the patients had concomitant diabetes,and clinical data and laboratory indexes were comprehensively collected from both groups.The clinical data and laboratory indexes of the two groups were collected comprehensively,including gender,age at onset,disease duration,season of onset,onset or exacerbation triggers,days of hospitalization,smoking,alcohol consumption,family history,body mass index,clinical typing,Chinese medical evidence,Psoriasis area and severity index(PASI)score,Chinese medicine prescriptions;blood pressure,triglycerides,high-density lipoprotein(HDL)at the time of hospital admission.triglycerides,HDL,LDL,lipoprotein(a),and uric acid.The disease information database was established using EXCLE,and the data were processed using SPSS26.0 software.And based on the ancient and modern medical case cloud platform,we analyzed the pattern of herbal formulae grouping medication received by patients with psoriasis with diabetes mellitus.Results:1.Among 426 patients with psoriasis,there were 77 patients with diabetes,accounting for18.08% of the total number,including 45 males and 32 females.There were 349 patients without diabetes,accounting for 81.92%,including 172 males and 177 females.2.Univariate analysis suggested that age at first presentation,duration of disease,smoking,body mass index,triglycerides,HDL,and LDL were statistically different between the two groups(P<0.05);the psoriasis with diabetes group was statistically different in terms of gender,season of onset,onset or exacerbation triggers,days of hospitalization,alcohol consumption,family history,clinical typing,Chinese medical evidence,PASI score,blood pressure,lipoprotein(a),and uric acid were not statistically different(P>0.05).3.Multifactorial logistic regression analysis suggested that smoking(OR=3.687,95%CI=1.846-7.361),body mass index(OR=1.581,95% CI=1.353-1.846),duration of illness(OR=1.062,95% CI=1.035-1.090),and age at first presentation(OR=1.054,95%CI=1.022-1.087)were significantly associated with whether psoriasis was associated with diabetes mellitus.4.The 71 prescriptions included for the treatment of psoriasis with diabetes mellitus involved a total of 150 Chinese herbs,and the top 10 in terms of frequency of use were: Dihuang,Atractylodes,Mudanpi,Medlar,Licorice,Radix Paeoniae,Astragalus,Angelica,Bupleurum and Poria in that order.5.The medicinal properties of herbs used in the treatment of psoriasis with diabetes mellitus were mainly cold(644 times,52.15%),warm(310 times,25.10%),and flat(209 times,16.92%),and the medicinal flavors were mainly bitter(754 times,40.21%),sweet(652 times,34.77%),and pungent(251 times,13.39%).(661 times,21.00%),heart meridian(527 times,16.74%),lung meridian(466 times,14.80%),stomach meridian(444 times,14.10%),and spleen meridian(388 times,12.33%).6.A total of 24 core Chinese medicine association rules were obtained,and the top three association rules in terms of confidence,support and improvement were "Angelic a-Atractylodes","Atractylodes-Dihuang" and "Mudanpi-Dihuang The top three associatio n rules in terms of support and enhancement were "Angelica-Acupuncture","Atractylo des-Bezoar" and "Mudanpi-Dihuang".7.Cluster analysis was performed for high-frequency herbal medicines,and four herbal medicine classifications could be obtained: Class I: Medlar,Astragalus,Radix et Rhizoma,Radix Paeoniae,Radix et Rhizoma,Mudanpi;Class II: Fu Ling,Licorice,Atractylodes;Class III: Angelicae Sinensis,Radix Rehmanniae;Class IV: Poria,Forsythia,Sempervivum,Rhizoma alba,Salviae Miltiorrhizae,Hydrophilus,Comfrey,Rhizoma Bupleurum,Sophora.8.The core prescription of Chinese medicine for the treatment of psoriasis with diabetes mellitus is Gentian Diarrhea Liver Soup,Tao Hong Si Wu Tang with Angelica Sinensis Six Yellow Soup plus reduction.Conclusion:1.In this study,smoking,body mass index,course of disease and age of first onset are the main risk factors of psoriasis complicated with diabetes.2.In this study,gender,season of onset,onset or exacerbation triggers,days of hospitalization,alcohol consumption,family history,clinical staging,TCM evidence,PASI score,blood pressure,triglycerides,HDL cholesterol,LDL cholesterol,lipoprotein(a),and uric acid status were not relevant risk factors for psoriasis with diabetes in patients with psoriasis.3.In this study,"Radix Angelicae Sinensis and Atractylodes Macrocephala" is the core pair of Chinese medicine for the treatment of psoriasis with diabetes mellitus;clearing heat,dispelling dampness,activating blood circulation,cooling blood,resolving blood stasis and detoxifying toxins,benefiting qi,nourishing yin and moistening dryness are the main guiding ideas of Chinese medicine for the treatment of psoriasis with diabetes mellitus.