Study On The Prescription Compatibility Rules Of Professor Lv Guanhua In Treating Gastroesophageal Reflux Disease By Combining Disease And Syndrom

Purpose: The purpose of this study is to explore the rules of formula preparation of Prof.Guanhua Lv in the treatment of GERD,and to deeply explore his discursive features,in order to provide new ideas for the prevention and treatment of GERD and improve the clinical efficacy.Material and method:From January 2020 to December 2022,the medical records of patients with gastroesophageal reflux disease who were treated by Professor Lu Guanhua in the Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine were collected as the research object.237 cases were included in the screening according to the admission criteria.The case data were preprocessed and standardized,and entered into Microsoft Office Excel to establish a database.Analyze the frequency of the collected relevant materials and data of traditional Chinese medicine,analyze the association rules of traditional Chinese medicine,and systematically cluster the middle and high frequency traditional Chinese medicine.Results:1.Among 237 cases of GERD patients in this study,102 were male and 135 were female,with a male to female ratio of about 1:1.32.the onset was mainly in middle-aged and elderly people,with the largest number of people between 60 and 69 years old,amounting to 69,followed by 57 people between 50 and 59 years old.2.Among the 237 cases in this study,the symptoms of acid reflux and heartburn were the most frequent,230 and 195 times,respectively,while belching(145 times),poor sleep(132 times),gastric distention and fullness(130 times),bitter mouth(91 times),dry mouth(85 times),and gastric pain(73 times)were also more frequent.The tongue is most often light red;the tongue coating is most often thin white;the pulse is most often string pulse.As for the types of symptoms,liver-stomach disharmony(68 cases)was the most frequent,followed by liver-stomach heat(64 cases)in the second place.3.Among the 237 prescriptions in this study,there are 163 kinds of traditional Chinese medicines,with a total frequency of 3343 times.The single drug with a frequency of 40 or more is considered as high-frequency drugs,with a total of 20 flavors.The efficacy of drugs used in treatment is mostly qi-regulating drugs.Among the four-qi properties of traditional Chinese medicine used to treat diseases,the frequency of cold application is the most.Among the five flavors,bitter drugs appeared most frequently,followed by pungent drugs,sweet drugs ranked third,and salty,light,astringent and sour drugs all appeared less.The frequency of drugs that belong to spleen meridian is the highest,followed by lung meridian,and the frequency of traditional Chinese medicine belonging to sanjiao meridian,small intestine meridian,bladder meridian and pericardium meridian is less.4.The drugs collected from 237 cases were analyzed by association rules,and the minimum support was set at 10% and the minimum confidence was 80%,resulting in a total of 44 association rules for drug pairs,with the commonly used pairs being cuttlebone → zhebei mum,muxiang → malt,Chenpi → heliotrope,and hemihsia → huanglian.With a minimum support of 30% and a minimum confidence level of 90%,a total of 34 second-order association rules were obtained,and the commonly used combinations of three drugs were Chenpi→Cangzhi and Houpao,Hexia→Fu Ling and Chenpi,etc.A total of three core prescriptions were mined through cluster analysis,formula 1: Chen Pi,Hou Pei,Cang Zhu,Mu Xiang,Ma Ma Ma,Zhe Bei Mao,and Hai Mantou;formula 2: Gan Cao,Chai Hu,Ginger,Scutellaria,Radix Codonopsis,Jujube,Huang Lian,and Gan Jiang;formula 3: Atractylodes,Citrus Aurantium,Paeoniae,Perillae Stems,Poria,Sempervisia,Radix Aromaticae,Gardenia,and Rhizoma Chuanxiong.Conclusion:1.Prof.Guanhua Lv believes that the basic pathogenesis of GERD is the failure of the spleen and stomach qi to rise and fall,and that "heat" is the main pathogenic factor,so the treatment is based on the basic method of "regulating the qi" and the prescription of medicine according to the different types of GERD and different symptoms.2.Prof.Guanhua Lv makes good use of classic prescriptions in treating gastroesophageal reflux disease,combines disease differentiation with syndrome differentiation,and pays attention to the harmony and health of stomach qi.The core prescription embodies the treatment ideas of promoting qi movement,clearing away heat and dampness,harmonizing stomach and invigorating spleen,regulating cold and heat,removing annoyance and relieving depression.