Data Mining On The Correlation Between Female Chloasma Syndrome And Constitution And Its Treatment With Traditional Chinese Medicin

Purpose: Collect the clinical information,TCM syndrome type and TCM constitution type distribution of female chloasma patients,and analyze the correlation between clinical information,physique and syndrome type,so as to provide diagnosis and treatment basis for clinical prevention and treatment of chloasma.And data mining is carried out on the literature of clinical trials of oral Chinese medicine in the treatment of chloasma,and the rules and characteristics of traditional Chinese medicine in the treatment of chloasma are obtained,which provides new ideas and methods for the syndrome differentiation and treatment of chloasma.Material and method:1.Thesis I: a total of 197 female patients with chloasma were selected from the Dermatology Clinic of the affiliated Hospital of Liaoning University of traditional Chinese Medicine from December 2020 to August 2022.Their onset age,course of disease,family history,menstruation,reproductive history,TCM syndrome type and TCM constitution type were collected,and a database was established.Chi-square test was carried out on the relationship between clinical information,physique and syndrome type by SPSS27.0.P < 0.05 indicates that there is statistical significance between them.If there is statistical significance between physique and syndrome type,the specific relationship between physique and syndrome type of chloasma is analyzed by Logistic regression.2.Thesis Ⅱ :The literature comes from the database of China knowledge Network,and the retrieval period is from August 2002 to August 2022 for a period of 20 years.The literature is the clinical trial literature of traditional Chinese medicine in the treatment of chloasma.The collected information of syndrome differentiation,drug classification,frequency of use of traditional Chinese medicine,drug properties,drug taste and drug menstruation were statistically analyzed.SPSSModeler18.0 and SPSS27.0 were used to analyze the association rules and cluster of high frequency drugs.Results:Thesis I:1.Among the 197 patients with chloasma,the syndrome of liver depression and qi stagnation was the most,78 cases(about 39.6%),followed by qi stagnation and blood stasis syndrome,52 cases(about 26.4%),34 cases of liver and kidney yin deficiency syndrome(about 17.3%),and 33 cases of spleen deficiency and dampness syndrome(about 16.8%).2.In 197 patients with chloasma,the correlation analysis between clinical data and syndrome type showed that there was statistical significance between TCM syndrome type and age,course of disease,site of skin lesion and menstrual cycle(P < 0.05).The main syndrome of20-39 years old is liver depression and qi stagnation,40-49 years old is liver kidney yin deficiency;the course of disease is liver depression and qi stagnation within 5 years,and the course of disease is more than 6 years;butterfly skin lesions are mainly liver depression and qi stagnation syndrome,generalized skin lesions are mainly liver and kidney yin deficiency syndrome,facial medium skin lesions are mainly qi stagnation and blood stasis syndrome,and mandibular skin lesions are spleen deficiency and dampness syndrome.The main syndrome of menstrual cycle is liver depression and qi stagnation in 25-38 days and more than 38 days,and spleen deficiency and dampness syndrome in menstrual cycle less than 25 days.3.Among the 197 patients with chloasma,15 cases(7.60%)were mild and 182 cases(92.40%)were biased.There were 44 cases(22.30%)with single constitution(excluding peaceful quality)and 138 cases(70.10%)with sandwiched constitution.There were 77patients(39.10%)with two kinds of constitution,40 cases(20.30%)with three kinds of constitution,and 21 cases(10.70%)with more than three kinds of constitution.The distribution of physique was as follows: qi stagnation(101 cases),blood stasis(71 cases),yin deficiency(53 cases),qi deficiency(46 cases),phlegm-dampness(44 cases),yang deficiency(40 cases),dampness-heat(39 cases),peace(15 cases)and special nature(15 cases).In this study,the distribution relationship between syndrome type and physique was statistically significant(P < 0.05).The syndrome of liver depression and qi stagnation was dominated by qi depression,the syndrome of qi stagnation and blood stasis was dominated by qi stagnation,and the syndrome of spleen deficiency and dampness was dominated by phlegm-dampness.the syndrome of yin deficiency of liver and kidney is mainly yin deficiency.The specific relationship between the constitution and syndrome type of chloasma by Logistic regression analysis showed that the quality of qi depression and blood stasis were positively correlated with the syndrome of liver qi stagnation,while the quality of qi deficiency and yang deficiency were negatively correlated with the syndrome of liver qi stagnation;the quality of qi depression and blood stasis were positively correlated with the syndrome of qi stagnation and blood stasis,and the quality of yin deficiency was negatively correlated with the syndrome of qi stagnation and blood stasis;the quality of phlegm-dampness and yang deficiency were positively correlated with the syndrome of spleen deficiency and dampness;and the quality of qi depression and spleen deficiency and dampness were negatively correlated.Qi deficiency and yin deficiency were positively correlated with liver and kidney yin deficiency syndrome,while qi depression was negatively correlated with liver and kidney yin deficiency syndrome.ThesisⅡ:1.According to the retrieval method,1241 articles were retrieved,and the literatures were selected according to the inclusion criteria and exclusion criteria.Finally,216 articles were selected and 240 were included in the group.2.The top 4 syndrome types were liver depression and qi stagnation(83),qi stagnation and blood stasis(60),liver and kidney yin deficiency(37),spleen deficiency and dampness obstruction(16).3.Traditional Chinese medicine has a total of 2773 uses,and there are 18 categories of traditional Chinese medicine.the top five commonly used drugs are 41 drugs for tonifying deficiency,41 drugs for clearing heat,involving 30 medicines,21 medicines for promoting blood circulation and removing blood stasis,17 medicines for relieving appearance,and 12 medicines for regulating qi.4.The top 10 were Angelica sinensis(205 times),Poria cocos(142 times),Radix Paeoniae Alba(133 times),Bupleurum(131 times),Ligusticum chuanxiong(113 times),safflower 109 times,peach kernel 87 times,licorice 85 times,Salvia miltiorrhiza 84 times,Atractylodes macrocephala 83 times.5.The medicinal properties are mainly warm,cold and flat,followed by cold and hot.The statistical frequency of medicine taste is mainly sweet,bitter and pungent,followed by sour,light,salty and astringent.Meridians are mainly attributed to liver,heart,spleen and kidney,followed by lung,stomach,gallbladder and so on.6.The analysis of drug association rules showed that the top five confidence levels were Angelica-Atractylodes macrocephala-Radix Paeoniae Alba,Radix Atractylodis macrocephala,Radix angelicae Sinensis-Rhizoma Chuanxiong,Radix angelicae Sinensis-Rhizoma Chuanxiong,Radix angelicae Sinensis-Radix Paeoniae Rubra-Safflower,and Radix angelicae Sinensis-Radix Paeoniae Alba-Radix Paeoniae Alba,Radix angelicae Sinensis-Radix Bupleuri.High-frequency drug cluster analysis showed that the four new prescriptions were: Ligustrum lucidum-yam-Cornus officinalis-Radix Rehmanniae-Cortex moutan;Rhizoma Ligustrum-Yujin-Bupleurum-Radix Paeoniae Alba-Angelica-Poria-Atractylodes macrocephala-licorice;peach kernel-safflower-red peony-Radix Rehmanniae-Chuanxiong;Salvia miltiorrhiza-motherwort-Angelica dahurica-Bombyx mori-dodder.Conclusion:1.The common syndrome of female patients with chloasma is the syndrome of liver depression and qi stagnation,and there is a correlation between TCM syndrome and age,course of disease,type of skin lesions and menstrual cycle.2.The main types of constitution are qi depression,blood stasis,yin deficiency,qi deficiency and phlegm-dampness.There is a correlation between syndrome type and physique,so we can prevent and treat chloasma by regulating the type of physique,and in the process of syndrome differentiation and treatment of chloasma,we should take into account the type of patient’s physique and regulate the treatment of physique.3.Through the summary of the clinical trial literature,it is found that the clinical treatment of chloasma is mainly tonifying deficiency,promoting blood circulation and removing blood stasis,and Angelica sinensis,Poria cocos,Radix Paeoniae Alba,Bupleurum and other drugs are often used.Four new prescriptions are obtained by cluster analysis,the first three are: Liuwei Dihuang decoction,Xiaoyao Powder and Taohong Siwu decoction,indicating that modern doctors pay attention to the application of ancient prescriptions and add and subtract them combined with clinical manifestations on the basis of ancient prescriptions.the last one is Salvia miltiorrhiza,motherwort,Angelica dahurica,Bombyx mori,dodder,paying attention to the treatment of chloasma from the wind.The rule of drug use is obtained by data mining,which can provide a new idea for the clinical treatment of chloasma.