| Objective:To observe the clinical effect of Xiongshi Shiwei Wendan Decoction on stable angina pectoris of unstable angina pectoris complicated with depression.Methods:The patients with unstable angina pectoris of coronary heart disease who were admitted to Hunan Provincial Hospital of Traditional Chinese Medicine from December 2021 to January2023 were selected as the study subjects.They were numbered according to their admission time,and were divided into observation and control groups by random number table method,with 33 patients in each group.The patients in the two groups were treated with standardized western medicine treatment plan for unstable angina pectoris,while the patients in the control group were treated with droperidol melitracen tablets on the basis of the standard treatment plan;The patients in the observation group were treated with Xiong’s Shiwei Wendan Decoction on the basis of standardized western medicine.The general data of patients before treatment were compared,and the two groups of patients were comparable.All patients received standard treatment for 2 weeks,and recorded the scores of Hamilton Depression Scale-17(HAMD-17)before and after treatment,the symptoms of angina pectoris before and during treatment,the scores of TCM symptom scale before and after treatment,as well as the objective indicators such as heart rate and blood pressure,and made statistical analysis.The difference was statistically significant with P<0.05.Results:1 The age range of patients in the observation group was(47～89)years old,with an average age of(72.70 ± 10.48)years.There were 16 male and 14 female patients;The age range of the control group was(47～86)years,with an average age of(72.60 ± 8.59)years.There were 15 male and 15 female patients.There was no statistical difference between the two groups in gender,age and other basic data(P>0.05).There was no statistical difference between the two groups in the clinical data of CCS angina grade,prevalence of basic diseases(hypertension,hyperlipidemia,diabetes)and other clinical data(P>0.05).2 Before treatment,there was no significant difference between the two groups in the score of HAMD-17 scale(P>0.05);After treatment,the score of HAMD-17 in the two groups was significantly lower than that before treatment(P<0.05),but the score of HAMD-17 in the observation group was significantly lower than that in the control group(P<0.05).3 Before treatment,there was no statistical difference between the two groups in TCM syndrome score before treatment(P>0.05),which was comparable.After treatment,the total score of TCM syndrome in both groups decreased significantly(P<0.05),but the total score of TCM syndrome in the observation group was lower than that in the control group(P<0.05).4 Before treatment,there was no statistically significant difference in the score of angina symptoms between the two groups of patients(P>0.05);After treatment,the score of angina symptoms in both groups of patients showed a significant decrease(P<0.05),but the total score of traditional Chinese medicine syndrome in the observation group was lower than that in the control group(P<0.05).5 There was no significant difference in systolic blood pressure,diastolic blood pressure and heart rate between the two groups before treatment(P>0.05);After treatment,the systolic blood pressure,diastolic blood pressure and heart rate of the two groups decreased compared with those before treatment,and the difference was statistically significant(P>0.05);The systolic blood pressure and heart rate of patients in the observation group after treatment were lower than those in the control group(P<0.05).6 During the treatment,there were no obvious adverse reactions such as liver and kidney dysfunction,coagulation dysfunction,nausea and vomiting in both groups.Conclusion:1 Xiong Shiwei Wendan Decoction can significantly improve depressive symptoms in patients with unstable angina and depressive state.2 Xiong Shiwei Wendan Decoction can exert a good therapeutic effect on the symptoms of angina in patients with unstable angina and depressive state,and at the same time,it can play a better control effect on the symptoms of Chinese medicine in patients,and it has a better application prospect in the treatment of patients with unstable angina.3 Xiong Shiwei Wendan Decoction Combined with western medicine conventional treatment of unstable angina pectoris with depressive status(phlegm stasis blocking collaterals syndrome)has no obvious adverse effects,high safety and efficacy,and has a relatively broad application prospect,which is worth promoting. |
PDF Full Text Request