| Objective: By analyzing the general information,biochemical test results,and imaging data of patients with chronic total occlusion of coronary artery disease with different traditional Chinese medicine(TCM)syndrome types,this study aims to explore the clinical characteristics of different TCM syndrome types and provide references for the diagnosis and treatment of chronic total occlusion of coronary artery disease using a combination of TCM and Western medicine.Methods: Select 100 consecutive CTO coronary heart disease patients who underwent coronary angiography or PCI treatment and were admitted to the Cardiology Department of the First Affiliated Hospital of Hunan University of Chinese Medicine between January 1,2021 and June30,2022.Collect general information,traditional Chinese medicine(TCM)diagnosis,biochemical test results,imaging data,etc.of the patients,classify the TCM syndrome types,and conduct statistical analysis of the distribution and clinical features of the TCM syndrome types in combination with relevant patient information.Results: 1.General information: The study included 100 patients,with 79 males and 21 females,a male-to-female ratio of 3.76:1,and an average age of 61.52±1.05 years.2.Distribution of TCM syndromes: The frequency of TCM syndrome distribution among the patients included in the study was as follows: phlegm-heat obstructing syndrome in 41 cases(41.0%),phlegm-stasis obstructing syndrome in 21 cases(21.0%),qi-yin deficiency syndrome in 20 cases(20.0%),and qi-stagnation and blood-stasis syndrome in 18 cases(18.0%).3.Comparison of CTO patients among different TCM syndromes:(1)Gender: There was no significant difference in gender distribution among patients with different syndromes(P>0.05).(2)Age: The average age of patients with qi-yin deficiency syndrome was significantly higher than that of the other three groups,and the difference was statistically significant(P<0.05),while there was no significant difference among the other three groups(P>0.05).(3)BMI: The BMI level of patients with qi-yin deficiency syndrome was significantly lower than that of patients with other syndromes,with statistical significance(P<0.05),while there was no significant difference among the other three groups(P>0.05).(4)Personal history: There was no significant difference in smoking and drinking history among patients with different syndromes(P>0.05).(5)Past medical history:There was no significant difference in the history of hypertension and diabetes among patients with different syndromes(P>0.05).(6)Inflammatory indicators: The PLR of patients with phlegm-heat obstructing syndrome was significantly higher than that of the other patients(P<0.05),while there was no statistical difference in the WBC,LYM,and PLT indicators(P>0.05).(7)Blood lipid status: The TC of patients with phlegm-heat obstructing syndrome and phlegm-stasis obstructing syndrome was significantly higher than that of patients with qi-stagnation and blood-stasis syndrome and qi-yin deficiency syndrome(P<0.05),while there was no statistical difference in the TG,HDL-C,and LDL-C indicators(P>0.05).(8)Blood sugar status: There was no significant difference in FPG among patients with different syndromes(P>0.05).(9)Imaging data: There was no statistical difference in LVEF and collateral circulation among patients with different syndromes(P>0.05),while the Gensini score of patients with phlegm-heat obstructing syndrome was significantly higher than that of patients with qi-stagnation and blood-stasis syndrome and phlegm-stasis obstructing syndrome(P<0.05).Conclusion: 1.In this study,patients with coronary chronic total occlusion(CTO)lesions were mainly middle-aged and elderly individuals with an average onset age of around 60 years,with male patients significantly more than female patients.They often have unhealthy habits such as smoking and drinking,as well as underlying diseases such as hypertension and diabetes.2.In terms of traditional Chinese medicine(TCM)syndrome differentiation,the distribution of CTO patients with coronary heart disease in this study from highest to lowest was phlegm-heat stasis syndrome,phlegm-stasis mutual obstruction syndrome,qi-yin deficiency syndrome,and qi stagnation and blood stasis syndrome.3.In this study,patients with qi-yin deficiency syndrome had the lowest BMI;patients with phlegm-heat stasis syndrome and phlegm-stasis mutual obstruction syndrome had higher total cholesterol levels than those with qi stagnation and blood stasis syndrome and qi-yin deficiency syndrome.Patients with phlegm-heat stasis syndrome had the highest inflammation indicator PLR.4.In this study,CTO patients with phlegm-heat stasis syndrome had a higher Gensini score,indicating worse coronary artery conditions. |
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