Clinical Observation On The Treatment Of Premature Ovarian Insufficiency, Amenorrhea And Spleen And Kidney Deficiency With Zhuluan Decoctio

Objective:The purpose of this study is to observe the clinical effect of ZhuLuan Recipe on POI patients with spleen and kidney deficiency syndrome from three angles of TCM syndrome,laboratory examination and imaging examination,so as to provide theoretical basis for improving the quality of life of patients and improving their physical and mental health.Methods:This study selected 60 patients who were diagnosed as POI by western medicine and were diagnosed as amenorrhea,spleen and kidney deficiency syndrome by traditional Chinese medicine from January 2022 to October 2022 in the gynecology clinic of the First Affiliated Hospital of Hunan University of Traditional Chinese Medicine.The patients were randomly divided into control group and treatment group with 30 cases each,and all of them volunteered to participate and signed the informed consent form.The control group was treated with pure western medicine HRT,and took Complex Packing Estradiol Tablets/Estradiol and Dydrogesterone Tablets(manufacturer:Abbott Healthcare Products B.V.registration certificate number:H201 10208),1 tablet/day,a total of 28 days after withdrawal,and began to take the next cycle of drugs on the third day of withdrawal bleeding,a total of 3 menstrual cycles.The treatment group was treated with the traditional Chinese medicine prescription of invigorating the spleen and tonifying the kidney,warming the nest and nourishing the bubbles under the guidance of the "Iceberg theory" on the basis of the western medicine HRT treatment in the control group,with a total of 3 menstrual cycles.All traditional Chinese medicines in the treatment group were uniformly boiled by the pharmacy of our hospital,and each dose was decocted into 200ml under normal pressure and sealed.The patients began to take one dose a day,twice in the morning and evening,and took warm medicine 30 minutes after meals.Each cycle was treated for 28 consecutive days and 3 consecutive cycles.After three cycles of treatment,statistical software was used to analyze and compare the TCM syndrome score,sex hormone-related indicators(FSH,LH,E2,AMH),bilateral ovarian volume and number of sinus follicles in the two groups.Results:(1)Comparison of overall effective rate:the cure rate of the control group was 10%,the significant effective rate was 16.67%,the effective rate was 50.00%,and the overall effective rate was 76.67%;In the treatment group,the cure rate was 16.67%,the significant effective rate was 40.00%,the effective rate was 33.3 3%,and the overall effective rate was 90.00%;The curative effect of the two groups after treatment was statistically significant(P<0.05).(2)Comparison of TCM syndrome score:the comparison between the two groups before and after treatment was statistically significant(P<0.05).After treatment,the TCM syndrome scores of the two groups were statistically significant,and the treatment group was lower than the control group(P<0.05).(3)Comparison of sex hormone-related indicators:The difference between the two groups of patients with the same hormone level before and after treatment was statistically significant(P<0.05).After treatment,the levels of F SH and LH in the two groups were significantly decreased,and the levels of E2 and AMH were significantly increased.After treatment,the levels of various hormones in the two groups were statistically significant(P<0.05),and the FSH,LH decreased and E2,AMH increased in the treatment group than in the control group.(4)Comparison of imaging related indicators:the bilateral ovarian volume of patients in the two groups was statistically significant before and after treatment(P<0.05),but the ovarian volume of patients in the two groups was not statistically significant after treatment(P>0.05).The number of ovarian sinus follicles on both sides of patients in the two groups was statistically significant before and after treatment(P<0.05).The number of ovarian sinus follicles in the two groups was statistically significant before treatment(P<0.05),and the increase of AFC in the treatment group was better than that in the control group.Conclusion:ZhuLuan Recipecan effectively treat the primary and secondary symptoms of POI patients with amenorrhea and spleen and kidney deficiency syndrome,reduce the levels of FSH and LH,and increase the levels of E2 and AMH.From the perspective of imaging,it can increase the number of ovarian sinus follicles.Under the guidance of the "Iceberg Theory" of invigorating the spleen and nourishing the spleen,warming the nest and nourishing the bubbles,ZhuLuan Tang can nourish the ovaries,assist in conception,and promote the physical and mental health of patients.