Study On The Correlation Between Yang Deficiency And Cold Stagnation Syndrome And Bone Metabolism Indexes In Knee Osteoarthriti

Objective: To observe the difference between yang deficiency and condensation syndrome of knee osteoarthritis and non-yang deficiency and cold condensation syndrome in bone metabolism and other indicators,and the correlation between yang deficiency and condensation syndrome of knee osteoarthritis and bone metabolism and other indicators.Methods: 74 patients with knee osteoarthritis who met the inclusion criteria were selected and divided into the yang deficiency cold condensation syndrome group and the non-yang deficiency cold condensation syndrome group according to the identification results,which were included in the observation group and the control group,respectively.The observation indexes included pre-collagen type I N-terminal peptide(PINP),osteocalcin medium molecular peptide(N-MID),type I collagen cross-carboxy-terminal peptide β-collagen sequence(β-CTX),blood calcium ions and blood phosphorus ions(Ca,P),bone mineral density,total cholesterol,triglycerides,high-density lipoprotein,low-density lipoprotein,K-L classification and Chinese medicine symptom score.We compared the differences of bone metabolism and other indexes between the observation group and the control group and the correlation between the TCM symptom scores and bone metabolism and other indexes of the observation group.Results: A total 74 cases were collected,including 38 cases in the observation group and 36 cases in the control group.There was no difference between the two groups in terms of gender and age(P>0.05),and they were all comparable.The N-MID and PINP of bone metabolic indexes in the observation group were higher than those in the control group,and the difference between the two groups was statistically significant(P < 0.05).The differences between the two groups in β-CTX,blood phosphorus and blood calcium were not statistically different(P < 0.05).The bone mineral density of the observation group was lower than that of the control group,and the difference was statistically different(P < 0.05).There was no statistically significant difference between the groups of K-L grades in the observation and control groups(P>0.05).There was no statistically significant difference between the groups of total cholesterol,triglycerides,high-density lipoprotein and low-density lipoprotein in the observation group and the control group(P>0.05).By Spearman correlation analysis,the yang deficiency cold condensation evidence score in the observation group was positively correlated with PINP,bone mineral density,and total cholesterol(P < 0.05),and not with other indexes(P < 0.05).Conclusion: 1.Knee osteoarthritis with syndrome of yang deficiency and cold condensation correlated with bone metabolic indexes PINP,bone mineral density,and total cholesterol.2.KOA patients with syndrome of yang deficiency and cold condensation syndrome had higher serum PINP,N-MID,and lower bone mineral density,suggesting that the KOA syndrome of yang deficiency and cold condensation group may have a high conversion state of bone metabolism and a risk of osteoporosis.