Study On The TCM Syndrome And Treatment Rules Of Asthma-COPD Overla

Objective: To collect the cases of clinical asthma complicated with COPD,analyze the distribution rule of overlapping TCM syndromes of asthma-COPD,and provide reference for the clinical dialectical and basic research of TCM.Materials and METHODS: In this study,according to the strict inclusion and exclusion criteria,case data of inpatients in the respiratory Department of the Affiliated Hospital of Liaoning University of Traditional Chinese Medicine were collected.Excel and SPSS 21.0 statistical software were used for cluster analysis of clinical symptoms and signs of patients with asthma-COPD overlap,so as to explore the distribution of TCM syndrome types of this disease.The drugs used for treatment were entered into Microsoft Office Excel to establish a database,and the information of the four qi,five flavors,and meridian tropism of the drugs was statistically analyzed.Apriori algorithm of SPSS Modeler 18.0 software was used to analyze the association rules of high-frequency drugs.Cluster analysis of drugs was performed by SPSS21.0 softwareResults:1.A total of 62 cases were collected in this study,and the gender distribution of asthmaCOPD overlapping patients was more male(74%)than female(26%);2.The minimum age was 45 years old and the maximum age was 74 years old.The patients were divided into 6 age groups,including 3 cases aged 45-49 years old,6 cases aged 50-54 years old,9 cases aged 55-59 years old,17 cases aged 60-64 years old,22 cases aged 65-69 years old,and 5 cases aged 70-75 years old;3.50 patients with history of smoking or passive smoking,accounting for 80.6% of the total;4.Among the 62 patients,33 cases used the name of asthmatic syndrome in TCM diagnosis,accounting for 53.2% of the total number;25 cases used the name of croup disease,accounting for 40.3% of the total number.In addition,there are also "cough","lung swelling" as the corresponding TCM disease names.Chronic obstructive pulmonary disease was the first diagnosis in 37 cases,followed by bronchial asthma in 25 cases.5.Among all the symptoms,the frequency of cough was the highest,62 times,accounting for100%,indicating that asthma-COPD overlap patients had cough,followed by shortness of breath,red tongue,yellow and white sputum,and the frequency of yellow coating was 72.4%,62.9%,56.5%,56.5%,respectively.In addition,there were 14 symptoms with a frequency of more than 20%,including poor sleep,fatigue,chest tightness,phlegm in the throat,dry mouth,difficult phlegm/unfavorable discharge,dark red tongue,less sputum,deep and slippery pulse,slippery pulse string,less appetite,frequent urination,constipation/dry stool,and slippery pulse.Were accounted for 51.6%,40.3%,40.3%,37.1%,37.1%,35.5%,33.9%,32.3%,30.6%,30.6%,29.0%,25.8%,22.6%,21.0%.6.After cluster analysis,combined with clinical knowledge,asthma-COPD overlap was divided into 5 categories,including syndrome of phlegm-heat closing lung,syndrome of phlegm turbidity blocking lung,syndrome of Qi and Yin deficiency,syndrome of lung and kidney qi deficiency,and syndrome of phlegm-blood stasis blocking lung.7.Through data analysis,it was found that the high-frequency drugs used in the overlapping of asthma and COPD were Poria cocos,cornus officinalis,Platycodon platycodon,Mony peel,Astragalus membranaceus,Scutellaria baicalensis,Chinese yam,Rehmanniae radix,Schisandrae fructus,gesso,Perilla fructus,Atractylodes atractylodes,Codonopsis rhizoma,Pinellia pinellia,Ephedra,almond,Rhizoma alismatis,licorice and tangerine peel,and the main meridians of drugs were lung,spleen,stomach,kidney and heart meridians.Its properties were mainly warm,cold,flat and hot.The flavor of the medicine is sweet,bitter and spicy.8.The high frequency drug pair of common prescription was Poria cocos-Astragalus membranaceus.9.According to the cluster analysis,a total of 2 major classes of drugs were obtained,including class 1: scrophularia,loquat leaves,raw rehmannia,Radix paeoniae alba,Radix bupleuri,fried licorice,forsythiae forsythiae,Scutellaria baicalensis,gypsum,licorice,fritillaria fritillaris,Ephedra,almond,Perilla seeds,mulberry white bark,Radix descuraini,Pinellia,Angelica;2 types: Magnolia officinalis,shoot dry,cooked rehmannia,Schisandrae fructus,Astragalus membranaceus,Ophiopogonis ophiopogonis,Pachymaria coicis,Rhizoma alba,Rhizoma alba,Rhizoma alba,Rhizoma alba and Fritillaria alba.The included prescriptions were Qiwei Duqi pill and Maxing Shigan decoction.Conclusion:1.This study was based on the first diagnosis of TCM prescriptions and four diagnosis information of outpatients in the respiratory Department of the Affiliated Hospital of Liaoning Hospital of Traditional Chinese Medicine.It was concluded that most of the patients with asthma-COPD overlap belonged to the underlying deficiency and the underlying deficiency were mainly lung and kidney deficiency,and the standard excess was mainly the accumulation of various pathological products such as phlegm turbidity,phlegm heat,phlegm and blood stasis.2.Based on the cluster analysis of clinical symptoms,asthma-COPD overlap was divided into5 categories,including lung and kidney qi deficiency syndrome,phlegm-heat blocking lung syndrome,phlegm-turbidity blocking lung syndrome,qi and Yin deficiency syndrome,phlegm and blood stasis blocking lung syndrome.3.The drug cluster analysis of the patients showed that the included prescriptions were Qiweiduqi pill and Maxingshigan decoction,and their effects were taken as tonifying lung and kidney,clearing heat and relieving asthma.