Study On Clinical Characteristics Of 76 Cases Of Tumor-related Anemia Treated With Traditional Chinese Medicin

Objective:This study was based on a single-center real-world retrospective data collection and analyzed the clinical data of patients with tumor-associated anemia who were hospitalized at the Department of Hematology and Oncology,Dongzhimen Hospital,Beijing University of Traditional Chinese Medicine between February 28,2018,and February 28,2023,and met the inclusion criteria to study the real-world timing of the use of anemia-related proprietary Chinese medicines in patients with tumor-associated anemia,population characteristics,treatment for 4 weeks before and after hemoglobin count,improvement of overall functional status,and efficacy of TCM evidence and TCM symptoms,to provide a comprehensive evaluation of the current status of patients’ use of anemia-related proprietary Chinese medicines.The aim of the study is to obtain the current status of the use of proprietary Chinese medicines for the treatment of tumor-related anemia and the application groups,to provide reference for the clinical application of proprietary Chinese medicines for the treatment of tumor-related anemia,and to inherit and develop the advantages of Chinese medicine for the treatment of the disease.Method:This trial finally included 76 patients who were hospitalized at the Department of Hematology and Oncology,Dongzhimen Hospital,Beijing University of Traditional Chinese Medicine between February 28,2018 and February 28,2023 and met the criteria of nadir,and the population characteristics were analyzed for age,gender,TCM evidence type,type of tumor suffered,type of TCM used,and use of anti-tumor therapy,and the effectiveness was evaluated by comparing the changes in peripheral blood hemoglobin content and KPS score before and after 4 weeks of TCM use,and comparing the changes in Hb values before and after 4 weeks of TCM use between patients in the TCM treatment group and those in the iron treatment group.Results:1 The Chinese patent medicines used by patients with anemia hospitalized in Dongzhimen Hospital of Beijing University of Traditional Chinese Medicine within 5 years for the treatment of anemia were Yiqi Weihe Capsules,Jianquan Shenghe Tablets,Shenghebao Compound,and Compound Agaricus Syrup.Among them,Yi Qi and Blood Maintenance Capsules accounted for the most use,with a total of 57 patients,accounting for 75%.2 The age range of patients treated with anti-anemia TCM was from 60 to 79 years old,and the most common cancer types were gastrointestinal malignant tumors,pulmonary malignant tumors and gynecological malignant tumors,with patients with mild to moderate anemia.3 There were 21.1%of spleen and stomach deficiency evidence,15.8%of heart and spleen deficiency evidence,31.6%of liver and kidney yin deficiency,and 28.9%of spleen and kidney yang deficiency evidence.The liver and kidney yin deficiency evidence group and spleen and kidney yang deficiency evidence group were predominantly stage Ⅳ,and the heart and spleen two deficiency evidence were predominantly stage Ⅱ and stage Ⅳ,with statistical differences(P<0.05),and stage Ⅱ heart and spleen two deficiency evidence was more predominant than other tumor stages,with statistically significant differences(P<0.05):there were statistical differences(P<0.05)in the grading of anemia degree within different Chinese patent medicine application groups,with Jianshuang blood tablets tending to be mildly anemic and Compound Aconite syrup tended to be moderately anemic.4 There was a statistically significant difference in the difference of Hb level between the iron treatment group and the anti-anemia proprietary Chinese medicine treatment group before and after 4 weeks of treatment(P<0.05),and the proprietary Chinese medicine treatment alone had better efficacy than iron alone in improving the Hb level of patients.The antianemic proprietary Chinese medicine group was statistically significant in improving patients’ quality of life(P<0.05).Conclusion:The results of this study suggest that the use of Chinese herbal medicine for tumor-associated anemia can better improve Hb levels and improve patients’ self-conscious symptoms compared to hematopoietic material supplementation alone.Tumor-associated anemia is a common complication during tumor treatment.As the disease of tumor itself continues to worsen,it can lead to a series of problems such as weakness,immune deficiency,tumor recurrence and metastasis,etc.Improving anemia,increasing patients’ sensitivity to radiotherapy and improving survival quality have become the main direction of research on tumor-associated complications.Chinese medicine has a long history of treating anemia,and its treatment of tumor-associated anemia means it has the function of strengthening the spleen,tonifying the qi and generating blood to restore the immune function as soon as possible,and at the same time,it has a direct anti-cancer effect,which can make the organism recover faster and has the advantages of individualization,comprehensive treatment,enhancing immunity and reducing the side effects of chemotherapy.However,as the soup formula needs to be formulated by experienced TCM practitioners to achieve good therapeutic effects.Although the formula is fixed,it is convenient to use,eliminating the trouble of boiling and decocting,and it is easy to be used in modern clinical treatment,which is a good drug for patients with tumor-associated anemia.In the context of modern medical development model,in order to make TCM treatment of tumor-associated anemia more widely used in clinical practice,the population selection of TCM treatment should be actively studied,and the advantages of TCM treatment should be popularly developed to benefit clinical patients.