| Purpose:To evaluate the effectiveness and safety of acupuncture and moxibustion combined with Fushuliang in the intervention of moderate and severe allergic rhinitis,and provide evidence-based evidence for the acupuncture and moxibustion intervention program of moderate and severe allergic rhinitis.Method:This study focuses on patients with moderate to severe persistent allergic rhinitis and adopts a parallel randomized controlled study design.A total of 74 patients with allergic rhinitis were included,and 64 patients were ultimately completed.The treatment group adopted the intervention scheme of acupuncture,moxibustion+fluticasone propionate nasal spray,and the control group adopted the intervention scheme of fluticasone propionate nasal spray.The treatment group was given the intervention scheme of acupuncture and moxibustion three times a week for six weeks,and the two groups were given the nasal spray treatment of Fushuliang once a day for six weeks.Clinical evaluations were conducted at baseline,2 weeks,4 weeks,6 weeks,10 weeks,and 18 weeks of intervention.The primary outcome measure was the change in score of the Retrospective Total Nasal Symptom Score(rTNSS)scale compared to baseline at 6 weeks of intervention and 18 weeks of follow-up.Secondary outcome measures included Total Non Nasal Symptom Score(TNNSS),Total Ocular Symptom Score(TOSS),Rhinitis Control Assessment Test(RCAT)The Rhinoconjunctivities Quality of Life Questionnaire(RQLQ)measures the changes before and after six weeks of treatment compared to the baseline period.Evaluate safety by observing and recording adverse reactions and events during the patient’s treatment process.Result:1.In terms of main efficacy indicators:After 6 weeks of treatment(1-6 weeks),the total score of retrospective nasal symptom scale(rTNSS)before and after the treatment group was 5.69±2.99,and the control group was 1.75±3.21.There was a significant difference between the groups(P<0.05);At the end of the follow-up period(10-18 weeks),the treatment group was 1.16±3.06,and the control group was 0.93(±3.10),with differences between the groups(P<0.05).2.In terms of secondary efficacy indicators:In terms of the Total Non Nasal Symptom Score(TNNSS)scale,the change in total score before and after 6 weeks of treatment(1-6 weeks)was 2.72(±1.83)in the treatment group and 1.21(±1.62)in the control group,with significant differences between the groups(P<0.05);At the end of the follow-up period(10-18 weeks),the treatment group was 1.00(± 2.03)and the control group was 0.64(±2.28),with significant differences between the groups(P<0.05).In terms of the total score of eye symptoms(TOSS)scale,the change in total score before and after treatment for 6 weeks(1-6 weeks)was 2.56(±1.97)in the treatment group and 1.43(± 2.45)in the control group,with significant differences between the groups(P<0.05);At the end of the follow-up period(10-18 weeks),the treatment group had a score of 0.57(±2.01)and the control group had a score of 0.60(±2.33),with significant differences between the groups(P<0.05).In terms of the Rhinitis Control Assessment Test(RCAT)scale,the total score changes before and after 6 weeks of treatment(1-6 weeks)were 7.87(±5.42)in the treatment group and 3.18(±7.9)in the control group,with significant differences between the groups(P<0.05);At the end of the follow-up period(10-18 weeks),the treatment group had a score of 0.73(± 5.5)and the control group had a score of 2.24(±8.4),with significant differences between the groups(P<0.05).In terms of the Rhinitis Quality of Life Scale(RQLQ),the total score changes before and after 6 weeks of treatment(1-6 weeks)were 7.86(±19.63)in the treatment group and 5.83(±21.68)in the control group,with significant differences between the groups(P<0.05);At the end of the follow-up period(10-18 weeks),the treatment group was 16.44(± 21.63)and the control group was 11.01(± 22.47),with significant differences between the groups(P<0.05).3.Safety evaluation:No adverse events related to acupuncture or moxibustion.There were 4 cases of adverse events related to fluticasone propionate nasal spray,of which 3 cases had anaphylactic reaction after using Fushilang,and 1 case felt irritating smell after using Fushilang and it was too uncomfortable to flow back into the throat.No serious adverse events occurred in all patients.Conclusion:1.Both acupuncture and moxibustion and fluticasone propionate nasal spray are effective in treating allergic rhinitis,which can reduce the typical symptoms and accompanying symptoms of allergic rhinitis,and is an effective method to treat AR.The research results show that acupuncture and moxibustion combined with fluticasone propionate nasal spray is superior to fluticasone propionate nasal spray in improving AR patients,with significant improvement in the main symptoms,accompanying symptoms and quality of life.2.acupuncture and moxibustion combined with fluticasone propionate nasal spray is more sustainable than fluticasone propionate nasal spray alone for long-term efficacy of patients.The research results show that acupuncture combined with fluticasone propionate nasal spray and single fluticasone propionate nasal spray can improve the symptoms of AR patients,and acupuncture combined with fluticasone propionate nasal spray is more sustainable in long-term efficacy.3.Both groups have good safety,and acupuncture has higher safety. |
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