Meta-analysis Of The Effect Of Le Fort Ⅰ Osteotomy On Maxillary Bone Perfusio

OBJECTIVE:The purpose of this Meta-analysis was to evaluate the effect of Le Fort I osteotomy on maxillary blood flow and to provide guidance for clinical practice.METHODS:Observational studies on changes in maxillary perfusion in patients undergoing Le Fort I osteotomy were collected by searching relevant studies in PubMed,Web of Science,EMBASE,Cochrane Library,CNKI,VIP and Wan-fang databases,and the search time range was from database creation to March 2023.Meta-analysis was performed on studies that met the inclusion criteria after further completion of data extraction and quality assessment.Data were analyzed using RevMan 5.4.1,Total effect values and 95%confidence intervals were calculated,and the risk of bias was assessed for the included studies.RESULTS:6 cohort studies comprising a total of 171 patients were included in this study,Meta-analysis results showed that Le Fort I osteotomy significantly reduced immediate postoperative pulpal blood flow(SMD=-1.06,95%Cl[-1.99,-0.12],P=0.03),end-of-follow-up pulpal blood flow(SMD=-O.68,95%CI[-0.87,-0.49],P<0.00001),immediate postoperative gingival blood flow(SMD=-2.28,95%CI[-4.04,-0.51],P=0.01)and end-of-follow-up gingival blood flow(SMD=-3.36,95%CI[-5.25,-1.46],P=0.0005).Subgroup analysis showed differences between study outcomes using different outcome indicators reflecting maxillary bone perfusion.Conclusion:Maxillary perfusion is significantly reduced after Le Fort type I osteotomy.Differences exist in the changes in maxillary perfusion obtained using different indicators.To provide guidance for clinical practice,further investigation of the effects of different surgical techniques and indicators reflecting maxillary perfusion are required.