Analysis Of The Correlation Between The Distribution Of Body Constitution And Its Influencing Factors In Patients With Stage Ⅲ And Ⅳ Type 2 Diabetic Nephropath

OBJECTIVE: In this study,by arranging the general information,constitution types and physical and chemical indicators of 83 patients with type 2 diabetic nephropathy in stage Ⅲ and Ⅳ in the Department of Endocrinology,Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,the TCM constitution of patients with type 2 diabetic nephropathy in stage Ⅲ and Ⅳ was analyzed and processed.Types and their correlation with various influencing factors.In order to explore the factors that may affect the occurrence of stage Ⅲ and Ⅳ type 2 diabetic nephropathy,analyze the development law of the disease,and adjust the bias from the aspect of physique,so as to better achieve individualized prevention and treatment of diabetic nephropathy.By studying the TCM constitution of diabetic nephropathy,an effective reference is provided for the TCM treatment and early prevention and treatment of diabetic nephropathy.Materials and methods: A cross-sectional questionnaire survey was used to select 83 patients with stage Ⅲ and Ⅳ(type 2)diabetic nephropathy who visited the Department of Endocrinology,Affiliated Hospital of Liaoning University of Traditional Chinese Medicine from 2020-12-01 to 2021-12-31.After obtaining the consent of the patients,guide the completion of the questionnaire.The contents of the questionnaire include: general information,relevant physical and chemical examinations,and TCM constitution classification and judgment table.The general information includes name,age,gender,region,course of disease,height,weight,BMI,and pulse.,blood pressure,disease history,family history,tobacco and alcohol history,etc.;relevant physical and chemical tests include random blood sugar,glycosylated hemoglobin,triglyceride,total cholesterol,blood uric acid,glomerular filtration rate,serum creatinine,urea,urine microalbumin,Urine microalbumin/urine creatinine;the constitution judgment table adopts the 2009 version of the Chinese Medicine Association’s "Traditional Chinese Medicine Constitution Classification and Judgment Table" to determine the constitution.The data were organized into Excel tables,and SPSS 22.0 was used for data analysis.The distribution of TCM constitution types was described by composition ratio,the count data between groups were described by frequency and composition ratio,and the chi-square test was used for statistical inference.Binary Logistic regression algorithm was used to analyze the correlation between different constitution types and influencing factors.The test level α =0.05,P<0.05 means the difference is statistically significant,and P<0.01 means the difference is significant.Result:1.A total of 98 patients with stage Ⅲ and Ⅳ type 2 diabetic nephropathy were investigated,of which 15 were with incomplete data,and the final number of patients was 83.2.Among the 83 patients with stage Ⅲ and Ⅳ diabetic nephropathy,33 were female and 50 were male;13 were <50 years old,56 were between 50-69 years old,and 14 were over 70 years old;diabetic nephropathy Ⅲ There were 53 patients with stage Ⅳ disease and 30 patients with stage Ⅳ disease;41 patients had disease course of 0-10 years,28 patients had disease course of 11-20 years,13 patients had disease course of 21-30 years,and only 1patient had disease course of more than 30 years.3.The distribution of TCM constitution: 27 people(32.53%)with Qi deficiency,17(20.48%)with Yang deficiency,15(18.07%)with phlegm-dampness,13(15.66%)with Yin deficiency,and 13(15.66%)with Yin deficiency.4 people(4.82%),3 people with peaceful quality(3.61%),2 people with qi stagnation syndrome(2.41%),1 person with special temperament(1.21%),and 1 person with blood stasis quality(1.21%)4.In the results of this study,the occurrence of Qi deficiency was negatively correlated with the course of disease(P=0.029);the occurrence of Yin deficiency was negatively correlated with the level of BMI(P=0.022);the occurrence of phlegm-dampness was negatively correlated with the level of BMI It was positively correlated(P=0.007),and positively correlated with the level of triglycerides(P=0.011);the occurrence of yang-deficiency quality was related to gender,and it was more common in men;the occurrence of yang-deficiency quality was positively correlated with age(P=0.002),was positively correlated with serum creatinine level(P=0.008),and negatively correlated with glomerular filtration rate(P=0.039);the occurrence of damp heat was positively correlated with smoking and drinking history(P=0.013,0.002);The occurrence of urinary tract was negatively correlated with urinary microalbumin/urine creatinine(P=0.047).5.The results of binary logistic regression analysis showed that smoking was closely related to the occurrence of qi deficiency in DKD patients,and smoking was an independent risk factor for the occurrence of qi deficiency(B=0.155,P<0.01);urinary microalbumin was closely related to the occurrence of qi deficiency in DKD patients.Urinary microalbumin was an independent risk factor for the occurrence of Qi deficiency(B=0.004,P<0.01);BMI was closely related to the occurrence of phlegm-dampness in patients with DKD,and BMI was an independent risk factor for the occurrence of phlegm-dampness(B=0.377).,P < 0.05).Conclusion:1.The occurrence of this disease is related to gender,age and course of disease.Among them,there are more male patients than females;middle-aged and elderly patients are more likely to develop this disease;most of them have a course of 0-10 years.2.Patients with qi deficiency are more likely to suffer from diabetic nephropathy,followed by yin deficiency,yang deficiency and phlegm-dampness.3.The longer the course of diabetic nephropathy,the easier it is to form yang deficiency,and the shorter the course of disease,the closer it is to qi deficiency;patients with yang deficiency tend to have elevated serum creatinine levels and decreased glomerular filtration rate after suffering from diabetic nephropathy;patients with phlegm dampness After suffering from diabetic nephropathy,BMI level and blood lipid indexes are prone to increase.On the contrary,the BMI level of patients with yin deficiency type is generally lower after suffering from diabetic nephropathy.After diabetic nephropathy,patients with damp-heat type are found to have a history of smoking and drinking.4.Smoking and the increase of urinary microalbumin index are related to the formation of qi deficiency in patients with diabetic nephropathy;the increase of BMI is closely related to the formation of phlegm-dampness in patients with diabetic nephropathy.