Study On The Prescription And Medicine Rules Of Classical Prescriptions And Contemporary Prescriptions In Treating Adverse Reactions After Intervention Of Nasopharyngeal Carcinom

Objective: In this study,through searching,collecting and sorting out the literatures published in three major databases on adverse reactions after intervention of nasopharyngeal carcinoma treated by classical prescriptions and time prescriptions,the regularity of prescription use for adverse reactions after intervention of nasopharyngeal carcinoma treated by classical prescriptions and time prescriptions was analyzed.Using the technology and method of data mining,this paper analyzes the characteristics of drug use in the literature,Explore the rule of addition,subtraction and cutting of main prescription drugs.Based on network pharmacology,the possible molecular mechanism of Gancao Xiexin Decoction in treating radiation oral mucositis is explored,which provides reliable basis for clinical treatment and drug research.Materials and Methods: 1The key words were "nasopharyngeal carcinoma / head and neck tumor and traditional Chinese medicine / traditional Chinese medicine",and the retrieval time was from the establishment of the database to June 2020.The obtained literatures were screened according to the inclusion and exclusion criteria and finally included in the literature.Summarize the classic prescription and time prescription for the treatment of adverse reactions after intervention of nasopharyngeal carcinoma.2.To find out the articles containing specific drug treatment probable syndrome in the above-mentioned final included literature,summarize and count the probable syndrome and medication information with Excel table,and explore the addition and subtraction of the main prescription of adverse reactions after the intervention of classical prescription and time prescription in the treatment of nasopharyngeal carcinoma.three The chemical components and action targets of Gancao Xiexin Decoction were found in tcmsp,the compound disease target network,drug target protein and disease target protein(PPI)were constructed.Then go analysis and KEGG pathway enrichment analysis were carried out.Results:1.This study searched 476 articles in CNKI,704 articles in Wanfang,216 articles in Chongqing Weipu,deleted 487 duplicate articles,178 dissertations,100 conference papers,116 review articles,75 non-clinical research articles,27 nursing articles,146 non-classical prescriptions,70 incomplete prescriptions.After 50 literatures on other combined therapies,71 literatures on adverse reactions after intervention of nasopharyngeal carcinoma treated by classical prescriptions and time prescriptions were included.Among them,there are 44 literatures on the treatment of radiation oral mucositis,17 literatures on the treatment of radiation xerostomia,5 literatures on the treatment of radiation sinusitis,and 1 literature on the treatment of local swelling and hardness after radiotherapy.One document relate to that treatment of mouth opening limitation aft radiotherapy.There is one document about digestive tract reaction of chemotherapy,one document about bone marrow suppression of chemotherapy,and one document about targeted treatment of skin injury.2.This study involves 53 prescriptions,including 10 classic prescriptions and 43 time prescriptions.Among them,there are 35 prescriptions for the treatment of radiation oral mucositis,involving 2137 cases.Among them,there are seven classic prescriptions,mainly including rhubarb Huanglian Xiexin Decoction,Pinellia ternate modified bitter wine decoction,gypsum fangzhuye plaster decoction,Yin-nourishing Maimendong Decoction and Zengye Baihu Decoction.And other kinds of prescriptions,such as modified Dioscorea Pill and Hushen Decoction;There are 28 prescriptions,mainly including Yin-nourishing prescriptions headed by Yin-nourishing Qingfei Decoction,heat-clearing prescriptions headed by Daochi Powder and Siwu Decoction headed by Shengsiwu Decoction.Among them,20 articles involved 1213 cases,and the total effective rate of symptom relief ranged from83.33% to 97.2%.The remaining 24 articles involved 924 cases,The research results show that the curative effect of the treatment group(treated by classical prescription and time prescription)is better than that of the control group(treated by western medicine)(P<0.05).There are 13 prescriptions for the treatment of radiation xerostomia,involving 638 cases.Among them,one classic prescription is Guizhi Zhigancao Decoction,and there are 12 time prescriptions,mainly including Sijunzi Decoction modified by Sijunzi Decoction and Yin-nourishing Decoction modified by Shashen Maidong Decoction.Among them,11 articles involved 396 cases,and the total effective rate of symptom relief ranged from 73.1% to95.1%.The other six literatures involved 242 cases,and the research results all showed that the curative effect of the treatment group(treated by classical prescription and time prescription)was better than that of the control group(treated by western medicine)(P<0.05).Three prescriptions for the treatment of radiation sinusitis belong to the time prescription,involving 282 cases.The time prescription is Xiangsha Liujunzi Decoction plus Ganlu Disinfection Decoction,Shashen Maidong Decoction and Xanthium powder.Four literatures involved 247 cases,the total effective rate of symptom relief was between 92.2% and 98.06%,and the other one involved 35 cases.The results show that the curative effect of the treatment group(modified Xanthium powder)is better than that of the control group(western medicine)(P<0.05).3.A total of 21 articles were included in the research on the contingent syndrome of adverse reactions after the intervention of classical prescriptions and time prescriptions for nasopharyngeal carcinoma,involving 32 kinds of contingent syndromes,including 7 cases of dry mouth,8 cases of sore throat,4 cases of nausea and vomiting,7 cases of anorexia,2 cases of bitter mouth,3 cases of short and red urine,3 cases of insomnia,8 cases of constipation,2cases of epistaxis and 2 cases of nasal congestion.Six syndromes of qi deficiency(including qi deficiency,deficiency of qi and blood,deficiency of both qi and yin),the rest are spleen and stomach weakness,spleen and stomach deficiency and cold loose stool,gingival bleeding,loose stool,oral mucosa ulcer,dry lips and tongue or oral mucosa ulceration,deafness,dry throat,memory loss,tinnitus,deafness,red eyes,stagnation of qi and dampness,yellow and thick nose,accumulation of pus scab in nasopharynx,excessive phlegm coagulation and poison.Greasy tongue coating,purple or pale tongue,purple or dark tongue with ecchymosis,old and weak,and one RIOM without false membrane.4.A total of 21 literatures were included in the study of the probable syndrome of adverse reactions after intervention of classical and classical prescriptions for nasopharyngeal carcinoma,involving 24 kinds of commonly used therapeutic drugs.Among them,there are 4articles on common drugs for treating sore throat,2 articles on Radix Paeoniae Rubra and 2articles on Herba Taraxaci,and 5 articles on rhubarb and 5 articles on Fructus Cannabis.There are 7 articles about Trichosanthes kirilowii,3 articles about Phragmites communis and 2articles about Dendrobium nobile.There are 6 articles on malt,5 articles on Endothelium Corneum Gigeriae Galli and 2 articles on Massa Medicata Fermentata.There are 4 literatures about drugs commonly used in treating qi deficiency syndromes,including Astragalus membranaceus,Pseudostellaria heterophylla and Codonopsis pilosula.There are 3 articles about Pinellia ternata and 2 articles about Pogostemon cablin.There are 3 articles about common drugs for insomnia,2 articles about Polygonum multiflorum Thunb.and 2 articles about Semen Platycladi.There are 3 articles of lophatherum gracile and 2 articles of Akebia manshuriensis related to the most commonly used drugs for the treatment of urinary Huang Chi.There are 2 articles of Bupleurum chinense DC.about commonly used drugs for treating fever.There are 2 articles about Pueraria lobata,the most commonly used drugs for treating headache.There are 2 articles about Prunella vulgaris which are the most commonly used drugs for treating neck masses.5.Licorice diarrhea heart soup contains 246 active ingredients,1172 targets for radioactive oral mucositis,and 147 drug-disease common targets.The active ingredient of licorice soup is MOL000098(quercetin quercetin),MOL000422(kaempferol kaempferol),MOL000173(wogonin baicicalein),MOL004328(naringenin naringenin),MOL000392(formononetin burysin),MOL000358(beta-sitosterolβ-sitosterol),MOL003896(7-Methoxy-2-methyl isoflavone7-methoxy-2-methylisoflavones).Key targets involved in the treatment of radioactive oral mucositis include STAT3,TP53,JUN,MAPK3,AKT1,MAKP1,etc.The treatment of radiological oral mucositis includes Inflammatory mediator regulation of TRP channels(inflammatory mediators of TRP channels),Inflammatory bowel disease(inflammatory bowel disease),IL-17 signaling pathway(IL-17 signaling pathway),PI3K-Akt signaling pathway(PI3K-Akt signaling pathway)and other related pathways.Conclusion:1.In the study of prescription of classical prescription in the treatment of adverse reactions after intervention of nasopharyngeal carcinoma,the prescriptions of Nourishing Yin,clearing heat,gypsum,rhubarb,Siwu and Banxia can be used to treat radiation-induced oral mucositis;Yangjun prescription and its four kinds of prescription were mainly used in treating the disease;In the treatment of radiation sinusitis,sijunlei formula can be used as the main prescription;For the treatment of local swelling and hardness after radiotherapy,Yangyin,Qingre,Siwu and Huangqi can be used;It can be used to treat the limitation of mouth opening after radiotherapy.2.Among the prescriptions involved in this study,the Yangyin prescription Shashen Maidong decoction can treat radiation oral mucositis,radiation xerostomia,radiation sinusitis and local swelling and hardness after radiotherapy.The Yangyin prescriptions include Shengmai San and Yangyin Qingfei Decoction.The heat clearing prescriptions include Xiebai powder and Shashen Maidong decoction,Sijunzi heshengmai San and Chenxia Liujunzi Decoction were added and modified,and Chaihu Qinggan Decoction was added or subtracted to treat radiation oral mucositis and radiation xerostomia.3.There are 21 literatures about the probable adverse reactions after the intervention of nasopharyngeal carcinoma,including radiation oral mucositis,radiation xerostomia and radiation sinusitis.There are 32 kinds of probable syndromes.They were dry mouth,sore throat,nausea and vomiting,anorexia,bitter mouth,yellow red urine,insomnia,dry stool,epistaxis,nasal congestion,neck mass,headache,Cough,phlegm and blood,fever,Qi deficiency syndrome(including Qi deficiency,Qi deficiency and fatigue,Qi and blood deficiency,Qi and Yin injury),spleen and stomach weakness,cold and loose stool,gingival bleeding,loose stool,oral mucosal ulcer,dry lips and tongue or oral mucosa ulceration,deafness,dry throat,memory loss,tinnitus and deafness,red eyes,qi stagnation and dampness resistance,excessive yellow and thick nasal mucus,accumulation of purulent scab in nasopharynx,phlegm and toxin,and swallowing pain,Dizziness,greasy tongue coating,purple or light purple tongue,dark purple or ecchymosis,old and weak,Riom without pseudomembrane.4.Common drugs for treatment of probable syndrome: Belamcanda,radix paeoniae rubra and dandelion are the most commonly used drugs in the treatment of pharyngitis;Rhubarb and hemp seed are the most commonly used drugs for treating constipation;Trichosanthin,reed root and Dendrobium were the most commonly used drugs in the treatment of xerostomia;The most commonly used drugs for anorexia and anorexia were malt,chicken Neijin and Shenqu;Astragalus is the most commonly used medicine in the treatment of qi deficiency syndrome,Radix Pseudostellariae,Radix Codonopsis and Angelica sinensis;Pinellia ternate and Pogostemon were the most commonly used drugs for nausea and vomiting;The most commonly used drugs for insomnia were semen Ziziphi Spinosae,Radix Polygoni multiflori and semen Platycladi;The most commonly used drugs for the treatment of short red urine were Phyllostachys pubescens and Akebia manshuriensis;Radix Bupleuri is the most commonly used medicine for fever;Pueraria lobata is the most commonly used medicine for headache;Summer grass is the most commonly used medicine in the treatment of neck mass.5.In the drug research of the classical prescription for the treatment of nasopharyngeal carcinoma after intervention of adverse reactions: Agrimonia pilosa can be used for the treatment of epistaxis,but also for the treatment of cough,phlegm and blood;Rhizoma Imperata can be used to treat epistaxis and greasy tongue coating;Cornus officinalis can be used to treat tinnitus,deafness,dry throat and memory loss;Honeysuckle can be used not only for the treatment of dry lips and tongue or oral mucosa ulceration,but also for the treatment of phlegm and toxin.The common medicine pair combination has the treatment epistaxis,may use to the Agrimonia pilosa,the Imperata root;The treatment of nasal congestion can be Xanthium sibiricum,pungent catkin.6.For the treatment of radiological oral mucositis,Inflammatory mediator regulation of TRP channels,Inflammatory bowel disease,PI3K-17 signaling pathway and Akt signaling pathway are jointly regulated through multi-component and multi-target interactions.