Data Mining Of Prescriptions And Prescriptions For Aplastic Anemia Based On Ancient Chinese Medical Literatur

BackgroundAplastic anemia is one of the common blood diseases in China,the incidence rate of 7.4/10 million,can occur in all ages,the higher incidence of the elderly,male and female incidence was no significant difference,is a serious threat to people One of the healthy diseases of the blood system.Treatment of acute aplastic anesthesia mainly use allogeneic bone marrow transplantation,chronic aplastic anemia male hormone,immunosuppressive agents,hematopoietic cell growth factor and some symptomatic supportive therapy,so that patients with chronic aplastic anemia can be cured,or in the absence of blood transfusion,less blood transfusion The survival time and quality of the situation has been significantly improved,but there are many problems and deficiencies,the performance of drugs in the toxic side effects(such as male hormone damage and masculine,cyclophylline A renal toxicity and gastrointestinal reactions Etc.)serious impact on the quality of life of patients and even health,and bone marrow transplantation donor is difficult to match,some drugs are expensive,to carry out some difficulties.Chinese medicine practitioners for the disease similar to a lot of records,the symptoms,syndromes and aplastic anemia clinical manifestations are quite similar,so the motherland aplastic anemia belongs to the "virtual","blood ","Wasting "," marrow "and other areas.In recent years,the clinical use of traditional Chinese medicine or integrated traditional Chinese and Western medicine treatment of aplastic anemia has achieved a certain effect.Domestic physicians on the study of aplastic anemia mainly in the combination of their own clinical experience,to explain the pathogenesis of aplastic anemia pathogenesis,syndrome differentiation and the application of medicine and other aspects of understanding from the perspective of traditional literature collection and finishing aplastic anemia The knowledge is not much.PurposeThrough the review of traditional Chinese medicine,from which to extract the pathogenesis of aplastic anemia associated with the pathogenesis and treatment of traditional Chinese medicine treatment,and the use of literature research and modern statistical methods of the relevant side of the drug finishing research,the initial proof of ancient physicians on aplastic anemia Etiology and pathogenesis and treatment of prescription for the prevention and treatment of aplastic anemia to provide ancient literature based on the future of modern diseases for the study of ancient Chinese medicine to provide a reference.MethodFrom the pathogenesis of aplastic anemia of ancient Chinese medicine,the use of modern data mining to "Chinese Medical Code" for the search database,focusing on the use of "Chinese medicine support platform for the treatment of aplastic anemia recipe for data mining,to explore the ancient medical treatment A rule of prescription for aplastic anemia.The article was sorted out by retrieving the literature,and the relevant literatures were selected and sorted according to the information collection table.The MICROSOFT Excel worksheet was used to analyze the input data.SummaryA total of 275 prescriptions were used in the literature search.The total frequency of drug use was 2869 times,and the number of drugs used was 7.24.The results showed that there were 43 drugs with more than 14 times in the prescription,and the cumulative frequency was 1979,and the proportion of the total frequency was 64.97%.Therefore,the 43 kinds of Chinese medicine could be considered as the drug with higher frequency.1,aplastic anemia involved in the organs according to the frequency from high to low were kidney,liver,spleen,heart,stomach,lung.2,the prescription of the high-frequency drugs are mostly tonic drugs,heat medicine,diuresis and dampness medicine compatibility of the use of drugs.High frequency drug drug to warm flat,followed by cold and cool sex.The taste is mainly bitter,followed by the bitter taste.High frequency drugs are mainly by the kidney,followed by the liver,the spleen.3,the drug association rules analysis,get a higher correlation group 48,involving the drug 15 flavor.Treatment of aplastic anemia of the core drugs a total of 6 flavors,namely:Rehmannia,yam,dogwood,Poria,Alisma,Cortex Moutan.Conclusion1,the association rules for the great potential of high-frequency drugs and drug-related data related to the study has a certain feasibility.2,high frequency drugs are mainly tonic drugs,followed by heat medicine and hemostatic.Medicinal to warm mainly,followed by cold and cool.The taste is mainly bitter,followed by the bitter taste.The high frequency of drug-related taste in the literature reflects the characteristics of traditional Chinese medicine in treating aplastic anemia to a certain extent.From the point of view of dialectical treatment,high-frequency drug taste,category in line with the barrier of the virtual standard,cold and heat disorders of the pathogenesis characteristics.3,the use of association rules to obtain a strong combination of re-combination,including Rehmannia glutinosa and Rehmanniae,Rehmannia,Ligustrum lucidum and Eclipta,involving cinnamon,Dan,Salvia,Poria,Alisma and other 15 Chinese herbal medicine,These combinations reflect the treatment of aplastic anemia drug to tonic medicine and hemostatic combination,accompanied by heat medicine,diuresis moisturizing agent compatibility characteristics.