Analysis Of Clinical Features Of Portal Vein Thrombosis In Liver Failure Based On Cirrhosis

Objective To collect and analyze the clinical characteristics and risk factors of portal vein thrombosis(PVT)in patients with liver failure based on cirrhosis,and to evaluate the effect of PVT on the prognosis of liver failure,it provides theoretical basis for early detection of PVT and prevention of PVT formation.Methods Selected patients with cirrhosis-based liver failure admitted to the Ningxia Medical University General Hospital between January 2013 and October2022,including 59 patients with PVT and 123 patients without PVT,the general data,medical history,serological and imaging data of the two groups were analyzed statistically.Results1.There were significant differences in WBC,HGB,PLT,TBIL,GLB,ALT,AST,ALP,CHE,MELD score,Child-Pugh grade,creatinine,d-dimer,PTA,INR,TT,previous endoscopic treatment,esophageal-gastro varices bleeding(EGVB),portal vein diameter and systemic immune inflammation index between patients with and without PVT(P < 0.05),there was no significant difference in splenectomy(P > 0.05).2.Among 59 cases of liver failure with PVT,49 cases(83.05%,49/59)had complete obstructive PVT,and 10 cases(16.95%,10/59)had partial obstructive PVT.The mean MELD score of complete obstructive PVT was higher than that of partial obstructive PVT(P < 0.05).3.Among 59 cases of liver failure with PVT,32 cases(54.2%,32/59)were in the EGVB group and 27 cases(45.8%,27/59)were in the non-EGVB group,there were significant differences between the two groups in etiology,HGB,TBIL,AST,ALP MELD score,diameter of portal vein and previous endoscopic treatment(P<0.05).4.Among 59 cases of liver failure with PVT,there were 50 cases of chronic liver failure(84.7%,50/59)and 9 cases of acute-on-chronic liver failure(15.3%,9/59).There were statistically significant differences in TBIL and MELD scores between the two groups(P < 0.05).5.In patients with liver failure,endoscopic therapy,EGVB and portal vein diameter are risk factors for PVT.6.There was no significant difference in 10-month survival between liver failure with and without PVT(P = 0.407).Conclusion In patients with liver failure,previous endoscopic therapy and widening of portal vein diameter are risk factors for the formation of PVT.Patients with liver failure and PVT are prone to esophageal-gastro varices bleeding.It is important to prevent the occurrence of PVT in liver failure and reduce the occurrence of bleeding.