Analysis Of Clinical Data Of Patients With Abnormal Glucose Metabolism In Breast Cancer Chemotherapy

Objective To investigate the risk factors of abnormal glucose in breast cancer patients receiving chemotherapy.At the same time,explore the effect of chemotherapy-related abnormal glucose on the prognosis of female breast cancer patients in terms of disease-free survival.So as to provide theoretical basis for preventing the effect of chemotherapy on glucose metabolism in breast cancer and improving the prognosis.Methods A total of 387 female breast cancer patients admitted to General Hospital of Ningxia Medical University from January 2016 to December 2016 who received chemotherapy,had no previous history of diabetes and had normal fasting blood glucose before chemotherapy were retrospectively collected.Fasting glucose of patients during the treatment follow-up period was recorded.Relevant clinical data were collected including age,BMI,blood lipid index,parity,menopausal status,history of hypertension,tumor size,clinical stage,immunohistochemistry indexes,and chemotherapy regimen for univariate and multivariate analysis.The 3-year and 5-year disease-free survival rates were also observed.Results1.In 387 patients,269(69.5%)had normal blood glucose after chemotherapy and 118(30.5%)abnormal blood glucose after chemotherapy.2.Individual factor analysis showed that age ≥ 60 years,large body mass index,multiple parturition,menopause,triglycerides ≥ 2.26 mmol/L,large tumor diameter,late clinical stage,negative ER and PR,combination chemotherapy regimen,long chemotherapy cycle and cumulative dose of glucocorticoids ≥ 150 mg were relative risk factors for abnormal blood glucose after chemotherapy(P < 0.05).Further multifactorial regression analysis showed that age(OR=1.045,95% CI=1.003-1.090),triglycerides(OR=1.450,95% CI=1.039-2.025),and glucocorticoid dose(OR=1.006,95% CI=1.003-1.009)were independent risk factors(P<0.05).3.In the prognostic follow-up of 387 patients,disease-free survival was significantly lower in the post-chemotherapy abnormal glucose group than in the normal glucose group(χ2=4.669,P<0.05).Conclusion1.Advanced age,high triglycerides and high-dose glucocorticoid use are independent risk factors for the occurrence of glucose abnormalities in female breast cancer patients treated with chemotherapy.2.Large body mass index,multiple parturition,menopause,large tumor diameter,late clinical stage,ER and PR negative,long chemotherapy cycles,and combination chemotherapy regimens are relative risk factors for the occurrence of glucose abnormalities with chemotherapy in female breast cancer patients and will have an impact on blood glucose levels.3.Abnormal blood glucose due to chemotherapy is a risk factor for poor prognosis in breast cancer.