Analysis Of The Therapeutic Effect Of Drugs And Surgery On Non-invasive Prolactin Pituitary Adenoma

Objective To compare the efficacy of minimally invasive transsphenoidal pituitary adenoma resection and dopamine receptor agonist therapy in the treatment of non invasive prolactin type pituitary adenoma,and to provide some reference for the selection of treatment methods for the first diagnosis of non invasive prolactin type pituitary adenoma.Methods : The clinical data of patients with non-invasive prolactin-secreting pituitary adenoma treated with drugs or surgery as the initial treatment method from December 2016 to December 2022 in the Department of Neurosurgery,the First Affiliated Hospital of Kunming Medical University were retrospectively analyzed.142 patients were divided into drug and surgery group according to different treatment schemes,and the clinical data of each group were summarized and analyzed.Results :The recovery rate of gonadal function in the drug group was 80%,and that in the surgical group was 75.76%,with no significant difference(p>0.05).The remission rate of lactation symptoms in the drug group was 72.4%,while the remission rate of lactation symptoms in the surgical group was 90.9%,with no statistically significant difference(p>0.05).The relief rate of headache symptoms in the drug group was 81.2%,while the relief rate of headache symptoms in the surgical group was 88.6%,with no statistically significant difference(p>0.05).In terms of effectively reducing tumor volume,normalizing PRL after one year,and disease control rate,surgical treatment is superior to drug treatment,with a statistically significant difference(p<0.05).After 3months,there was no statistically significant difference in prolactin levels between medication and surgery(p>0.05).After 6 months and one year,surgical treatment was superior to drug treatment in reducing prolactin levels,with a statistically significant difference(p<0.05).Conclusion(s):1.Both drug treatment and surgical treatment are effective treatments for non-invasive prolactin-type pituitary adenoma.2.Experienced surgeons have proven effective in the treatment of non invasive prolactin type pituitary adenomas,and minimally invasive surgery via nasal transsphenoidal approach for pituitary adenoma resection is a preferred method.3.Patients receiving medication need to take medication for a long time and be followed up regularly.4.The treatment plan for patients with non-invasive prolactin-type pituitary tumor should be more individualized,and the advantages and disadvantages of drug and surgical treatment should be comprehensively discussed.