An Individual-matched Case-control Study Of The Association Between Leukocyte Counts And Meningiomas

Objectives:Inflammatory cells such as leukocyte in the blood are closely related to intracranial malignant tumors,but the relationship with intracranial benign tumors is not clear.Given that leukocytes in blood are an important part of the intracranial tumor microenvironment,they may also be potentially associated with intracranial benign tumors.At now,the lack of hematological markers in the diagnosis of meningioma.Therefore,this study intends to confirm the correlation of leukocyt with meningioma and their pathological grade,and to provide a theoretical basis for exploring the hematological markers of meningioma.Methods:A retrospective analysis was conducted of patients with meningioma diagnosed pathologically in our hospital from July 2019 to July 2022,and healthy individuals were matched through our hospital’s information center during the same period of physical examination.To exclude the effect of age and sex on leukocyte,we matched by age and sex in a 1:1 ratio.(1)Explore the difference of leukocyte between meningioma patients and matched control group,and clarify the correlation between leukocyte and meningioma;(2)Explore the difference of leukocyte between high-grade meningioma and low-grade meningioma by t-test of two independent samples,and confirm the correlation between leukocyte and the pathological grade of meningioma.Results:A total of 676 cases of meningiomas were included in the study,including 156 males(23.08%),520 females(76.92%),590 WHO grade I meningiomas(87.28%),82 WHO grade II meningiomas,and 4 WHO grade III meningiomas.WHO grade I meningiomas are defined as low grade meningiomas,and WHO grade II and WHO grade III meningiomas are defined as high grade meningiomas.The average age of the meningioma group and the control group was52.04±10.97 years old.(1)The leukocyte,neutrophil,lymphocyte,monocyte,eosinophil,leukocyte to lymphocyte ratio(LLY),and neutrophil to lymphocyte ratio(NLR)in the meningioma group were significantly higher than those in the control group,with a statistically significant difference(P<0.05).Binary Logstic regression analysis showed leukocyte>6.465×10~9/L,neutrophil,and gender were independent risk factors for meningioma,and the results were statistically significant(P<0.05).(2)The leukocyte,neutrophil,LLY,and NLR in the high grade meningioma group were significantly higher than those in the low grade meningioma group.The prevalence rate of women in the high grade meningioma group was higher than that in the low grade meningioma group,with a statistically significant difference(P<0.05).Binary Logstic regression analysis showed that gender was an independent risk factor for high-grade meningiomas,and the results were statistically significant(P<0.05).Conclusions:(1)Leukocyte and neutrophil are independent risk factors for meningioma,which can be used as feasibility factors for meningioma screening.(2)Based on the t-test,the high-grade meningioma group was significantly higher than low-grade meningioma in leukocyte and neutrophil;however,based on binary Logstic regression analysis,there was no significant statistical difference between leukocyte and neutrophilt in pathological grade of meningioma.(3)Sex was closely related to meningioma and it’s pathological grade.This study provides a theoretical basis for the exploration of cellular-level blood markers in meningioma and lays a foundation for further finding leukocyte-derived molecular markers in meningioma.