| Background and PurposeThere is a global epidemic of COVID-19 caused by SARS-Co V-2.Despite the aggressive response efforts that have brought the outbreak under some control,COVID-19 remains a threat to humans in the short term.We explore the differences in clinical manifestions,laboratory datas.imagings and prognosis between common COVID-19 and non-severe community-acquired pneumonia patients caused by low pathogenic human coronaviruses,so as to provide reference for better understanding of respiratory diseases caused by SARS-Co V-2.MethodClinical datas were collected from 38 patients with common COVID-19(group A)admitted to Harbin Infectious Disease Hospital from January to March 2020,36 patients with non-severe CAP caused by low pathogenic HCoVs(group B)admitted to the Second Affiliated Hospital of Harbin Medical University from January 2014 to December 2018,and 38 healthy individuals(group C)who underwent physical examination.The differences between basic information and laboratory indicators between the three groups were analyzed,and the differences in clinical symptoms,imaging manifestations and outcomes between patients in group A and group B were analyzed.Results(1)Basic information: The proportion of smokers in group B was significantly higher than that in group A and group C(healthy control group)(P<0.05),and there was no statistical difference between groups A and C(P>0.05).There were no significant difference in age,proportion of the elderly,gender and drinking history among the three groups(P>0.05).There was no statistical difference in underlying diseases between group A and group C(P>0.05).(2)Clinical symptoms: The symptoms of high fever(>39.0℃),cough,expectoration,chest distress and chest pain in group A were significantly less than those in group B(P<0.05).(3)Laboratory datas:(1)WBC and PLT:the level of WBC and PLT in group A was lower than group B and group C,and the difference was statistically significance(P<0.05).There was no statistical difference between groups B and C(P>0.05).NEU:Compared with group B and group C,the level of NEU in group A was lower(P<0.05),the level of NEU in group B was higher than that in group C(P<0.05).LYM:the level of LYM in groups A and B was lower than that in group C(P<0.05),and there was no statistical difference between groups A and B(P>0.05).(2)ALT and AST:patients in group A had higher levels than those in group C(P<0.05).The level of AST in group A was higher than that in group B(P<0.05).ALB:Compared with group C,patients in groups A and B had lower level of ALB(P<0.05),and there was no significant difference between groups A and B(P>0.05).SCr:The level in group A was lower than that in group B and group C(P<0.05),and there was no statistical difference between groups B and C(P>0.05).(3)D-Di:the level of D-Di in group A and group B was higher than that in group C(P<0.05),there was no significant difference between group A and group B(P>0.05).(4)hs CRP:the proportion of patients with elevated hs CRP in groups A and B was higher than that in group C(P<0.05),the proportion of patients with elevated hs CRP was higher in group B than that in group A(P<0.05).(4)Imaging findings: Consolidation,pleural thickening,pleural effusion were rare in group A and B.The incidence of ground-glass performance in group A was significantly higher than that in group B(P<0.05),and density performance of subconsolidation in group B was significantly higher than that in group A(P<0.05).(5)Outcome: The improvement rate was 97.4% in group A and 94.4% in group B;The rate of hospital transfer was 2.6% in group A and 2.8% in group B.The mortality rate was 0% in group A and 2.8% in group B,and there was no statistical difference in outcome between the two groups(P>0.05).Conclusion(1)There are differences in clinical characteristics between patients with common COVID-19 and patients with non-severe CAP caused by low pathogenic HCoVs.(2)Patients with common COVID-19 are more prone to suffer from liver function damage,while non-severe CAP patients caused by low pathogenic HCoVs are more prone to suffer from renal function damage.(3)Non-severe CAP patients caused by low pathogenic HCoVs are more likely to be accompanied with bacterial infection than common COVID-19 patients.(4)In terms of imaging,common COVID-19 patients mainly showed ground glass performance in both lungs,while non-severe CAP patients caused by low pathogenic HCoVs mainly showed subconsolidation in both lungs.(5)In addition,common COVID-19 and non-severe CAP caused by low pathogenic HCoVs are mostly seen in young adults without underlying diseases,with low mortality and good prognosis. |
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