| Retinal disease is a fundus disease,common retinal diseases are the following 5:A.vascular and vascular system lesions,such as retinal vascular obstruction,arteriosclerosis,hypertension,hematopathy and diabetic retinopathy.B.Retinal inflammation,closely related to choroidal inflammation and optic neuritis.C.Retinal detachment,refers to the separation of the retinal nerve layer from the pigmented epithelial layer.D.Retinal degeneration and malnutrition,etc.E.Retinal tumors,of which retinoblastoma is more common.In particular,diseases such as pigmented retinopathy(RP,retinitis pigmentosa)and diabetic retinopathy(DR)can cause retinal angiogenesis,vascular non-perfusion zone,loss of rod cell photoreceptor cells,etc.,which in turn causes visual field(VF,Visual field)defects and visual acuity(VA,Visual acuity)decline until the patient is completely blind.And there is currently no targeted and effective treatment.As an emerging means of retinopathy treatment,neuroelectrical stimulation has a very significant effect on some symptoms of retinal diseases with minimal drug treatment effect,especially retinal degenerative diseases.In recent years,invasive invasive retinal electrical stimulation in the field of artificial visual repair has a significant effect,and non-invasive retinal electrical stimulation has also been shown to protect retinal neurons.Transcorneal electrical stimulation(TES)as a new noninvasive retinal electrical stimulation therapy is used to improve vision(VF),increase the field of view(VF)range,and has received increasing attention in visual restoration therapy and assessment of retinal vascular pathways.However,so far,there is no corresponding treatment standard for different diseases of TES,so it is crucial to explore the effect of TES on the mechanism of retinal and choroidal blocked blood vessels.Optical coherence tomography(OCT)is a diagnostic tool that has developed into an unobtainable diagnostic tool in ophthalmology in recent years,and has rapidly developed into the "gold standard" for ophthalmic diagnosis with the advantages of in-vivo,non-invasive,real-time,high-resolution and three-dimensional tomography,and the functional extension of OCT technology Optical Coherence Blood Flow Imaging(OCTA,Optical Coherence Tomography Angiograph)has become a popular tool for the clinical diagnosis of lesions with its technical advantages of distinguishing dynamic microvascular vessels,removing static tissues,and realizing in vivo,threedimensional microangiography based on motion contrast.This topic will focus on the construction of the SS-OCT system and the response of the TES stimulation system.It is mainly to study the SS-OCT system for highresolution,high-definition fundus OCTA imaging in vivo,and track the response effect of TES to the treatment of fundus retinal diseases,obtain more accurate treatment parameters,and provide technical support for the diagnosis and treatment of ophthalmic diseases.The research content and innovative achievements of this project are listed as follows:(1)Design and build an SS-OCT system with a center wavelength of 1060 nm,a bandwidth of 105 nm,a scanning rate of 100 k Hz,a system lateral resolution of8.78μm,a longitudinal resolution of 7.4μm,and an imaging depth of 3.5mm.(2)The effect of 20 HZ,± 100 m A,±200m A,±300m A,and biphasic electrical stimulation on the treatment of retinal vascular pathway was studied,and was verified on living C57BL/6N mice. |
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