Serum Magnesium Leveland Prognosis Of Type 2 Diabetes Mellitus Complicated With Community-Acquired Pneumonia

Objective: To explore the effects of type 2 diabetes mellitus(T2DM)on serum magnesium levels in patients with community-acquired pneumonia(CAP)and the effect of abnormal serum magnesium on the prognosis in patients with T2 DM combined CAP.Methods: A retrospective study was conducted on adult patients hospitalized with CAP in The First Hospital of Qinhuangdao between January 2015 and December 2018.Data including : 1.Clinical data :information related to pneumonia、diabetes、ICU admission and hospital outcome were recorded from medical record;2.sociodemographic variables、physical signs、laboratory tests、the score of pneumonia;3.normal level of serum magnesium varies between 0.75 and 1.25mmol/L.All the above data are the results of the first test within 24 hours of the patient’s admission.Initial data on admission was extracted from the hospital information system and then produced into an excel sheet.These patients were devided into two groups according to T2 DM,control group and T2 DM group.The primary endpoint was in-hospital mortality.Results: The prevalences of hypomagnesemia,hypermagnesemia and abnormal serum magnesium in T2 DM group was slightly higher than that in control group(T2DM group: 14.6%,1.4% and 16.0%,respectively and control group: 12.0%,0.7% and 12.7%,respectively),but there was no statistical difference(P = 0.058).The score of pneumonia 、 the percentages of respiratory failure、 mechanical ventilation、 shock and ICU length of stay were higher in hypomagnesemic group than normal groups(P < 0.05).In patients with T2 DM,history of diabetes、 random blood glucose 、 the score of pneumonia were comparable in hypomagnesemic group and normal groups(P>0.05).In patients with T2 DM,the in-hospital mortalities in patients with normal serum magnesium and hypomagnesemia were 5.9% and 12.7%,respectively.In multiple logistic regression analysis,the in-hospital mortality of patients with hypomagnesemia was 4.736(95%CI: 1.806～12.422,P=0.002)times than the in-hospital mortality of patients with normal serum magnesium.Conclusion: Abnormal serum magnesium was common in inpatients with T2 DM combined CAP and hypomagnesemia was the most common.Hypomagnesemia was closely related to in-hospital mortality in patients with T2 DM combined CAP.The assessment of serum magnesium levels on admission was helpful in predicting the prognosis of patients with T2 DM combined CAP.