Analysis Of Influencing Factors Of Abdominalaortic Calcification And Cardiac Valve Calcification In Maintenance Hemodialysis Patients

Objective:The purpose of this study was to investigate the incidence of abdominal aortic calcification(AAC)and cardiac valve calcification(CVC)in patients with maintenance hemodialysis(MHD)and to screen independent risk factors for vascular calcification(VC)in patients with maintenance hemodialysis.Methods:1.According to the inclusion and exclusion criteria,a total of 114 patients with MHD from January 2020 to May 2022 were screened from the Hemodialysis Center of the Department of Renal Medicine of Hebei Provincial People’s Hospital,and Collect clinical data indicators of included patients;Abdominal lateral radiographs were performed to examine the calcification of the abdominal aorta.The diagnostic standard was to use Kuppila calcification score(AACS).According to the AACS score,the patients were divided into AACS<5 as no or mild calcification group,and AACS ≥ 5 as moderate and severe calcification group.By comparing the clinical indicators of calcification group and non-calcification group,the independent risk factors of ACC were analyzed by binary logistic regression.2.According to the cardiac valve calcification of 114 patients enrolled in the study,they were divided into valve calcification group and non-calcification group.SPSS27.0 software was used to statistically compare the clinical data and laboratory indicators of the two groups,and analyze the influencing factors of valve calcification.Results:1.114 hemodialysis patients were included in this study,including 65males(57%),49 females(43%),83 patients(72.8%)with abdominal aortic calcification and 79 patients(69.3%)with valve calcification.According to the score of abdominal aortic calcification,AACS<5 was classified as no or mild calcification group(31 cases),and AACS ≥ 5was classified as moderate or severe calcification group(83 cases);According to the condition of valve calcification,the patients were divided into valve calcification group(79 cases)and valve non-calcification group(35 cases).There were significant differences in age,dialysis age,KT/V,total cholesterol,low-density lipoprotein,corrected calcium,blood phosphorus,calcium phosphorus product,and there was statistical significance between moderate and severe calcification group and non-mild calcification group(P<0.05).Spearman correlation analysis showed that abdominal aorta calcification score was positively correlated with dialysis age,low density lipoprotein,total cholesterol,blood phosphorus,calcium and phosphorus product,and negatively correlated with KT/V.The results of binary logistic regression analysis showed that dialysis age(OR=1.084,OR 95% CI: 1.044～1.274,P<0.001),blood phosphorus(OR=4.512,OR 95% CI: 1.014～0.075,P=0.048),KT/V(OR=0.012,OR 95% CI: 0.001～0.841,P<0.001)were independent risk factors for abdominal aortic calcification.2.There were statistically significant differences in age,dialysis age,KT/V,combined hypertension,combined diabetes,C-reactive protein,total cholesterol,triglyceride,low density lipoprotein,corrected calcium,blood phosphorus,calcium phosphorus product and blood creatinine in valve calcification group(P<0.05).Stepwise Logistic regression analysis showed that dialysis age(OR=1.025,OR95%CI: 1.008～1.042,P=0.004),low density lipoprotein(OR=1.661,OR95%CI: 1.088～2.537,P=0.019),corrected calcium(OR=15.648,OR95%CI: 1.224～200.112,P=0.034)were independent risk factors for heart valve calcification.Conclusions:1.The research shows that the incidence of vascular calcification in maintenance hemodialysis patients is high,which needs to be paid attention to.2.In maintenance hemodialysis patients,dialysis age,blood phosphorus and KT/V were independent risk factors for abdominal aortic calcification.3.In maintenance hemodialysis patients,dialysis age,low density lipoprotein and corrected calcium were independent risk factors for cardiac valve calcification.