The Predictive Value Of Characteristics Of Very Early Recurrence After Persistent Atrial Fibrillation Radiofrequency Ablation On Long-term Prognosis

Purpose: To investigate the predictive value of burden characteristics of very early recurrence(VER)of persistent atrial fibrillation(AF)after radiofrequency catheter ablation(RFCA)on long-term prognosis.Methods: A total of 167 patients with persistent AF who underwent RFCA and developed VER in our hospital from July 2016 to February 2022 were selected.The daily onset time of AF within 7 days after ablation was recorded.The average,median,peak,time to peak,slope of peak,and time to fall back of AF burden were calculated.The end point of follow-up was any asymptomatic or symptomatic atrial tachyarrhythmia(AT)lasting >30s after 3 months of RFCA.Univariate and multivariate Cox regression were used to analyze the relationship between these characteristics and long-term prognosis.Results: After one year of follow-up,61% of VER patients had recurrence 3 months after RFCA.It was found that patients with peak of AF burden ≥75% had a higher incidence of postoperative AF recurrence,while patients with time to peak ≤2 days,slope of peak ≥50%/ day,time to fall back ≤ 4 days had a lower postoperative recurrence rate.In multivariate Cox analysis,peak and slope of peak of AF burden were independent risk factors for postoperative AF recurrence.Conclusions: The burden characteristics(peak,time to peak,slope,and time to fall back)of VER after RFCA in patients with persistent AF can predict long-term prognosis.The peak and the slope of peak of AF burden are independent risk factors for postoperative AF recurrence.