| Objective: To study the correlation between aneuploidy of chorionic villi and age,number of abortions,mode of conception and gestational age of abortion in patients with spontaneous abortion,and to explore the related risk factors of aneuploidy of chorionic villi in patients with assisted reproductive abortion,so as to provide scientific guidance for patients with eugenicism and better upbringing.Method:Clinical data of patients with spontaneous abortion(including patients with spontaneous pregnancy and assisted reproduction)who completed fetal villus chromosome aneuploidy detection in Affiliated Hospital of Guilin Medical University from March 2018 to December 2022 were retrospectively analyzed,including age,abortion frequency,pregnancy weeks,method of conception and assisted pregnancy data of patients with assisted reproduction.All spontaneous abortion patients were divided into chromosome abnormal group and chromosome normal group according to the villus chromosome detection results.The differences of age,abortion frequency,pregnancy weeks and conception mode between the two groups were compared.The data of assisted pregnancy in assisted reproductive abortion patients were compared,and the influencing factors of villus chromosome aneuploidy were analyzed by binary Logistic regression.Result: A total of 364 spontaneous abortion patients were collected in this study,including 193 cases in the abnormal group and 171 cases in the normal group.The abnormal rate of chromosome aneuploidy was53%.Trisomy 16 and trisomy 22 were the most common types of chromosome aneuploidy.The rate of chromosome aneuploidy abnormalities in age ≥35 years old group was significantly higher than that in age <35 years old group(χ2=9.97,P= 0.002),but there were no significant differences in the number of abortion,gestational week of abortion and mode of conception among all groups(P>0.05).Compared with natural pregnancy,assisted reproduction patients are more likely to have trisomy 15.The 163 patients with assisted reproduction were divided into normal chromosome group(72 cases)and abnormal chromosome group(91 cases),and there was no significant difference in baseline data between the two groups(P>0.05).The data of assisted pregnancy between the two groups showed that the abnormal rate of chromosome aneuploidy in patients aged ≥35 years was significantly higher than that in patients aged <35 years.There was no statistical significance in the distribution of ovulation promotion scheme,fertilization method and transplantation scheme in the normal and abnormal chromosome groups(P>0.05).Binary Logistic regression analysis was used to investigate the influencing factors of villus chromosome aneuploidy in patients with assisted reproductive abortion.The results showed that age and embryo quality had statistically significant effects on chromosome aneuploidy(OR=2.84,95% CI:1.35-5.94,P=0.006,OR= 3.29,95%CI: 1.16-9.28,P=0.025),the effects of other factors were not statistically significant.The chromosome aneuploidy rate of non-quality embryos transplanted at cleavage stage was significantly higher than that of quality embryos transplanted at cleavage stage(χ2=6.98,P=0.008),but there was no significant difference in the chromosome aneuploidy rate between non-quality embryos transplanted and quality embryos transplanted(P>0.05).Conclusion:1.Age is an independent risk factor for chromosome aneuploidy.2.There was no correlation between the occurrence of villus chromosome aneuploidy and the number of abortions,mode of conception and gestational age of abortion.Assisted reproductive technology did not increase the incidence of spontaneous abortion of chromosome aneuploidy.3.High-quality embryos should be selected to reduce the incidence of chromosome aneuploidy during the transplantation of cleavage embryos.There was no increase in the incidence of chromosome aneuploidy after blastocyst transplantation of nonprime blastocyst embryos. |
PDF Full Text Request