| ObjectiveTo observe the clinical efficacy and safety of Bushen Huoxue Decoction combined with drospirenone and ethinylestradiol tablets(Ⅱ)in the treatment of polycystic ovary syndrome(PCOS)of kidney deficiency and blood stasis type,and to provide more information ideas and objective basis for clinical diagnosis and treatment of patients with polycystic ovary syndrome of kidney deficiency and blood stasis type.MethodsAccording to the inclusion and exclusion criteria,88 cases of PCOS patients with syndrome differentiation of kidney deficiency and blood stasis who visited the Department of Obstetrics and Gynecology of Shanxi Provincial Hospital of Traditional Chinese Medicine from January 2021 to June 2022 were randomly divided into an experimental group of 44 cases and a control group of 44 cases.The control group was treated with conventional treatment by drospirenone and ethinylestradiol tablets(Ⅱ),and the treatment group was given traditional Chinese medicine Bushen Huoxue Decoction on the basis of the control group,and the course of treatment for both groups was 3 months.TCM syndrome scores,luteoinizing hormone(LH),luteoinizing hormone/follicle estrogen(LH/FSH)(Follicle stimulating hormone,FSH),and rogen(Testosterone,T),and body mass index,hirsute score and acne score changes were observed in the two groups before and after treatment,and recorded adverse reactions,statistics,and analysis of the clinical efficacy of Bushen Huoxue Fang combined with drospirenone and ethinylestradiol tablets(Ⅱ)in the treatment of this disease.Result1.Enrollment: Finally,85 cases completed the treatment,43 cases in the control group(drospirenone and ethinylestradiol tablets(Ⅱ)group),1 case dropped out;42 cases in the experimental group(Bushen Huoxue Fang combined withdrospirenone and ethinylestradiol tablets(Ⅱ)group),2 cases dropped out.2.Comparison of overall efficacy: the total effective rate of the control group was72.09% and the total effective rate of the test group was 90.48%,and the clinical effect of the test group was more obvious by chi-square test(P < 0.05).3.Comparison of TCM syndrome points: After treatment,the TCM syndrome points of both groups decreased significantly compared with those before treatment,with a significant difference(P < 0.05);the total TCM syndrome points of the two groups were statistically different(P < 0.05),and the TCM syndrome points of the test group were lower than those of the control group,indicating that the test group was significantly better than the control group in improving the TCM syndrome.4.LH,LH/FSH,T: After treatment,LH,LH/FSH and T decreased in both groups compared with those before treatment,which was statistically significant(P < 0.05);there was a statistical difference(P < 0.05)in the comparison of LH,LH/FSH and T between the two groups,and LH,LH/FSH and T in the test group were lower than those in the control group,indicating that the test group was better than the control group in improving LH,LH/FSH and T values was better than that of the control group.5.Acne scores: Compared to the pre-treatment period,both groups showed a significant decrease in acne scores after treatment,with a significant difference(P < 0.05);there was a statistically significant difference(P < 0.05)between the two groups,with the acne scores in the test group being lower than those in the control group,indicating that: the test group was significantly better than the control group in improving acne.6.Hirsutism scores: There was no significant change(P>0.05)in the hirsutism scores of patients in both groups before and after treatment within the group and between the two groups after treatment,indicating that: the efficacy of the two groups in reducing hirsutism symptoms was not significant.7.Body mass index: There was a significant difference(P < 0.05)between the two groups of patients in terms of body mass index after treatment compared with that before treatment,and both groups showed a significant decrease;there was no statistical difference(P > 0.05)between the two groups of patients in terms of body mass index after treatment,indicating that: the effect of the test group in terms of improvement in body weight was not significant compared with the control group.8.Recovery of menstruation after stopping the drug: the total effective rate of the control group was 72.09%,while the total effective rate of the test group was 90.48%.The recovery of menstruation after stopping the drug in the test group was better than that in the control group(P<0.05).9.The safety indexes of the two groups after treatment: blood routine,urine routine,liver function,blood and kidney function,electrocardiogram examination,etc.did not show any significant abnormalities.Conclusion1.Bushen Huoxue Decoction combined with Drospirenone and Ethinylestradiol Tablets(Ⅱ)can effectively improve the clinical symptoms of PCOS patients,improve acne,and promote menstrual recovery;2.Bushen Huoxue Decoction combined with Drospirenone and Ethinylestradiol Tablets(Ⅱ)can reduce the serum basic LH,LH/FSH and T values of PCOS patients,reduce body weight;3.Bushen Huoxue Decoction combined with Drospirenone and Ethinylestradiol Tablets(Ⅱ)in the treatment of PCOS has a low incidence of adverse reactions,which is a safe and effective treatment plan and worthy of promotion. |
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