| Objective: To observe the improvement degree of oral Guipi Decoction after colorectal cancer operation on the first postoperative exhaust time,defecation time,insomnia scale score,safety index,the number and degree of abdominal pain and abdominal distension,and postoperative hospital stay,etc.,so as to provide experimental basis for promoting gastrointestinal function recovery and sleep quality improvement after colorectal cancer operation,and through clinical trials,It provides a new idea for TCM to promote gastrointestinal function recovery and sleep quality improvement after colorectal cancer surgery.Methods: A total of 72 patients who underwent radical resection of colorectal cancer in the general surgery Department of Shanxi Hospital of Traditional Chinese Medicine from January 2022 to February 2023 and met the inclusion criteria were randomly divided into experimental group and control group according to random number table method,with 36 cases in each group.General data such as age,sex,operation method and operation duration were recorded and compared between the two groups.Patients in both groups were selected for radical operation of large intestine under the condition of improving relevant preoperative examination,intestinal preparation and fixed surgeon.Patients in both groups were routinely given analgesic,acid suppression,preventive anti-infection and other postoperative treatments,and were allowed to take liquid food 12 hours after surgery.Based on treatment in the control group,the experimental group was given Guipi Decoction(100ml BID PO)12h after surgery,and the relevant observation indexes were observed and recorded,including:(1)The time of first exhaust and defecation(2)The number and degree of abdominal pain and distension on the 1st,3rd and 7th day after surgery(3)The changes of laboratory indexes such as WBC,Hb,ALT,AST and Cr on the 1,3 and 7 days after surgery(4)the number of days in hospital after surgery.SPSS25.0 software was used for statistical data analysis.P<0.05 was considered statistically significant.Results: In the process of this study,there was 1 shedding in the control group and the experimental group,and 35 patients in the experimental group and the control group completed this study as required,with a total of 70 cases.There was no statistically significant difference in shedding rate between the two groups(P > 0.05).1.Baseline comparison: There were no significant differences in age,gender,surgical methods and operation duration between the two groups(P > 0.05).2.Comparison of the results of the first postoperative exhaust and defecation time: The comparison of the first postoperative anal exhaust time was statistically significant(P <0.05);The time of first defecation after operation was statistically significant(P < 0.05).Compared with the control group,the first postoperative exhaust and defecation time of the experimental group was shorter.3.Comparison of results of abdominal distension on the 1st,3rd and 7th day after surgery:There was no statistical significance in the degree of abdominal distension between the experimental group and the control group on the 1st day after surgery(P > 0.05).The degree of abdominal distension on the 3rd and 5th day after surgery was statistically significant(P < 0.05).On the 3rd and 7th day after surgery,abdominal distension in the experimental group was less severe than that in the control group.4.Analysis of abdominal pain severity scores at the 1st,3rd and 7th days after surgery:There was no statistical significance in the degree of abdominal pain at the 1st day between the experimental group and the control group(P > 0.05).The degree of abdominal pain on the 3rd and 5th day after surgery was statistically significant between the two groups(P <0.05).On the 3rd and 7th day after operation,the degree of abdominal pain in the experimental group was less than that in the control group.5.Analysis of the results of the comparison of sleep quality evaluation between the two groups: After comparison,there was no statistical significance in the scores of the Assens Insomnia Scale 24 h before surgery in the two groups(P > 0.05),but there was statistical significance in the scores of the Assens insomnia Scale in the two groups after 14 days of taking Guipi Decoction in the experimental group(P < 0.05).The scores of Athens insomnia scale in the experimental group were significantly lower than those in the control group.6.Analysis of laboratory test index results on the 1st,3rd and 7th day after surgery in the two groups: WBC count,Hb count,AST count,ALT count and Cr count were not statistically significant between groups(P > 0.05).7.Overall effect of gastrointestinal function recovery: experimental group was better than control group(P<0.05);8.Analysis of postoperative hospital stay in the two groups: After comparison,the postoperative hospital stay in the two groups was statistically significant(P < 0.05).Compared with the control group,the postoperative hospital stay in the experimental group was shorter.Conclusions:1.Compared with the traditional conventional treatment of colorectal cancer after root surgery,oral Guipi decoction can shorten the time of first operation exhaust and defecation of patients,reduce the degree of abdominal distension and abdominal pain of patients,improve postoperative sleep quality of patients,shorten the length of hospital stay of patients,and enable patients to return to work and learning environment earlier.2.TCM related treatment methods for the prevention and treatment of postoperative complications have the advantages of high safety and good therapeutic effect,and are worthy of vigorous clinical implementation. |
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