ObjectiveBy observing the use of celecoxib capsules combined with acupotomy under the guidance of the theory of bladder meridian sinew of foot-taiyang in the treatment of early ankylosing spondylitis,it is verified that the combination of traditional Chinese and Western medicine is more effective than simple drug treatment,with higher safety and more obvious advantages.It can be used as a future application of the theory of bladder meridian sinew of foot-taiyang in the treatment of early ankylosing spondylitis.This targeted implementation of the treatment plan provides clinical basis.MethodsThe experiment began in December 2018 and ended in January 2023.The cases were all from patients in the Department of Orthopedics and Pain of Shanxi Provincial Hospital of Traditional Chinese Medicine and volunteers recruited through other channels.A total of 60 patients with early ankylosing spondylitis who met the inclusion criteria and signed informed consent were admitted.The patients were randomly divided into two groups.Both groups were given celecoxib capsules,1 capsule/Qd,for 6 weeks.On the basis of oral medication,the treatment group was combined with the theory of bladder meridian tendon of foot sun to release the local tendon area(group A),and the distal tendon area(group B)was used according to syndrome differentiation,2 times/w,for 6 weeks.Observe the clinical efficacy of the two groups during treatment and follow-up,evaluate the scale and record the occurrence of adverse events.The main functional indicators of the study were ODI score,Sch(?)her test and occiput-wall distance.Laboratory data indicators included ESR and CRP.During the epidemic,telephone follow-up was the main method.The first follow-up was carried out at 3 weeks after the end of treatment,and the second follow-up was carried out at 6 weeks after the end of treatment.A total of 2 follow-ups were carried out.SPSS21.0 was used to analyze the data of the index scores,and the clinical efficacy of acupotomy intervention in early AS based on the theory of bladder meridian of foot-taiyang was evaluated.Results1.General data:There was no significant difference in baseline data between the control group and the treatment group(P > 0.05).2.Loss:During the treatment period,the progress was smooth and there were no shedding cases.3.Safety evaluation:mild adverse events such as stomach pain were reported in the control group during the treatment period,and one patient in the treatment group was treated with corresponding communication and treatment due to fear of needle knife pain.4.Outcome measures:(1)Main outcome indicators:ODI score:After the S-W(Shapiro-Wilk)test,the data of each group obeyed the normal distribution,and the ODI score data of the two groups before and after treatment were analyzed by repeated measures analysis of variance.Different treatment time points F = 21905,P = 0.00 < 0.05,indicating that the main effect of different treatment time points was significant,suggesting that the two groups were different before and after treatment.Different treatment time points*group F = 311.86,P = 0.00 < 0.05,indicating that the interaction between the two groups and time was significant.Due to the interaction between the two factors in this experiment,the simple effect was analyzed emphatically.There were P < 0.05 between the two groups before treatment,3 weeks and 6weeks,suggesting that both groups were effective before,during and after treatment,and the treatment effect of the treatment group was better than that of the control group.(2)Secondary indicators: Sch(?)her,occiput-wall distance,ESR and CRP were analyzed by repeated analysis of variance.The results showed that P < 0.05 at different treatment time points and different treatment time points*groups,indicating that the main effect of different treatment time points was significant,suggesting that Sch(?)her,occiput-wall distance,ESR and CRP in the two groups were different before,during and after treatment,and the interaction effect between the two groups and time was significant.Simple effect :Sch(?)her,pillow wall distance,ESR and CRP between the two groups before and after treatment were P < 0.05,indicating that there were differences in Sch(?)her,pillow wall distance,ESR and CRP between the two groups before,during and after treatment,and the treatment group was better than the control group.(3)Clinical efficacy: The total effective rate of the treatment group was 90.0% higher than that of the control group 73.3%.By Rank Sum Test,Z=-2.002,P<0.05,the treatment group was considered to be significantly more effective than the control group.ConclusionBased on the theory of bladder meridian sinew of foot sun,this experiment studied the treatment of early AS with acupotomy.The relevant experimental data confirmed that the treatment effect was superior,which could significantly relieve pain and improve the spinal joint mobility of patients,and inhibit inflammation to a certain extent. |