Association Of Perisomal Components And Dietary Nutrients And Preeclampsia Between Pregnancy(10-20⁺⁶)

ObjectiveTo explore the relationship between body composition and dietary nutrients of pregnant women at(10-20⁺⁶)weeks of pregnancy and the incidence of preeclampsia（PE）,analyze and compare the differences in body composition and nutrient metabolism between pregnant women with PE cases and normal control pregnant women(10-20⁺⁶),and look for high-risk factors for the incidence of PE,which provides a basis for clinical work.MethodsA total of 8874 pregnant(10-20⁺⁶)weeks pregnant women who underwent prenatal examination in the outpatient clinic of the Perinatal Medical Center of Gansu Provincial Maternal and Child Health Care Hospital from February 2021 to February 2022 were selected as the study subjects into the prospective observation cohort,and the general data,body composition and nutritional analysis data of pregnant women were collected,pregnancy outcomes were followed,and pregnant women diagnosed with PE were included in the PE case group using nested case-control research methods,with age as the matching condition and healthy pregnant women as the control group 1:1.To explore the relationship between body composition and dietary nutrition and the incidence of PE in pregnant women at(10-20⁺⁶)weeks.SPSS 26.0 statistical software was used for data analysis,and（P<0.05）indicated that the difference was statistically significant.Results1.A total of 8874 survey subjects were included in the study,and 204 pregnant women with PE were hospitalized in Gansu Provincial Maternal and Child Health Care Hospital,including 76 pregnant women with early-onset PE and 128 pregnant women with late-onset PE.2.Body mass index（BMI）,percentage of body fat（PBF）,Fat mass（FM）,Fat mass index（FM）,Fat mass index（FMI）,Fat free mass index（FFMI）,and weight gain during pregnancy（Gestational）between PE case group and control group Weight gain,GWG)and BMI in labour were statistically significant（P<0.05）,while fat free mass index（FFM）was not statistically significant between the two groups（P>0.05）.3.The daily intake of protein and fat between PE case group and control group(10-20⁺⁶)weeks was statistically significant（P<0.05）,and the daily carbohydrate intake between the two groups was not statistically significant（P>0.05）;the daily intake of vitamins between the two groups,except vitamin A（VitA）,vitamin B6（VitB6,VitB6）,vitamin B12（vitamin B12,VitB12）,There was a significant significance in vitamin B1（vitamin B1,VitB1）,vitamin B2（vitamin B2,VitB2）,vitamin C（VitC）,vitamin E（VitE）and folic acid（P<0.05）;the daily intake of minerals between the two groups,in addition to calcium and magnesium,was statistically significant in phosphorus,potassium,sodium,iron,zinc,copper and manganese（P<0.05）.4.The weekly fat energy supply ratio between PE case group and control group（10-20+6）was statistically significant（P<0.05）,the carbohydrate energy supply ratio and protein energy ratio between the two groups were not statistically significant（P>0.05）,and the physical activity level（PAL）between the two groups was not statistically significant（P>0.05）.5.After logistics regression analysis,among the 8 independent variables included,FMI was statistically significant,and FMI≥7.37kg/m²（OR=3.246,95%CI:1.607～6.557）and FMI≥9.73kg/m²（OR=9.113,95%CI:1.875～44.290）were risk factors for the incidence of PE.There were no significant significance in BMI,PBF,FM,FFMI,daily iron intake,folic acid daily intake and age at 10-20⁺⁶ weeks gestation（P<0.05）.Conclusions1.During pregnancy,attention should be paid to monitoring pregnant women(10-20⁺⁶)weeks BMI,PBF,FM,FMI,FFMI and GWG,especially for pregnant women with BMI≥28kg/m²,PBF≥38.41%,FMI≥9.73kg/m²,FFMI≥15.65kg/m²,strengthen prenatal examination,advise them to moderate activities,control GWG,and prevent PE from oral low-dose aspirin in the first trimester to term.Fetal size and fetal movements should be monitored in the third trimester to avoid adverse pregnancy outcomes,fetal heart rate monitoring should be strengthened during delivery,and venous thrombosis and postpartum hemorrhage in both lower extremities should be prevented after delivery.2.Monitor serum iron levels,supplement iron supplements,strengthen prenatal examinations,and avoid premature birth and low birth weight of newborns with a daily iron intake of<17.03mg in the week of pregnancy(10-20⁺⁶).For pregnant women with a daily intake of folic acid of 324.1 ug<324.1 ug at(10-20⁺⁶)weeks,folic acid genetic testing was perfected,folic acid supplementation was supplemented according to the degree of risk,and blood routine and homocysteine levels were regularly monitored.3.FMI at(10-20⁺⁶)weeks of pregnancy is a risk factor for the incidence of PE,for pregnant women with high BMI during prenatal examination in the first trimester,body composition examination,combined with FMI to assess their obesity,combined with GWG to give diet and exercise guidance,encourage pregnant women to change their lifestyle,and perform glucose tolerance test screening in the first trimester to monitor blood glucose and blood lipid fluctuations in the third trimester.