Modeling Of Heterogeneous Porous Bone Tissue Scaffolds And Morphological And Characteristic Analysis

With the development of bone tissue engineering and rapid prototyping technology,bone tissue engineering scaffolds composed of porous structures have become the most effective way to treat large-scale bone defects,and the establishment of personalized bionic scaffolds to meet the needs of different cases has become the core of bone tissue engineering.At present,there are still many difficulties in designing and manufacturing bone tissue scaffolds with appropriate biomimetic degree,biological activity and mechanical properties.Therefore,in this paper,in the field of bone tissue engineering,based on the reconstruction design of biomimetic bone tissue section and layered scaffold model,the morphology of bone hole of bone tissue section is evaluated and described,and the bearing capacity and flow field characteristics of non-uniform porous bone tissue scaffold are studied with the help of finite element method.Specific work includes:According to the characteristics and distribution of bone hole contours in real bone tissue sections,after regular exploration and extraction,a Python program algorithm for reconstructing bone tissue sections with bionic significance was developed,and a multilayer sectioning modeling method for bone tissue scaffolds was designed with the help of modeling software CAD,and the reconstructed bone tissue sections of the algorithm were successfully applied to the reconstruction of bionic bone tissue scaffolds,and finally a porous bone tissue scaffold with real exoskeleton contours was established.The porosity,specific surface area and connectivity of the reconstructed biomimetic bone tissue scaffold were analyzed,and the design parameters of the scaffold: average pore size,slice layer thickness,search radius,and the relationship with the physical properties of the bone tissue scaffold were explored,which provided a basis for the study of the mechanical flow field characteristics of the subsequent scaffold and the selection of future bone tissue scaffolds.A variety of mathematical morphological methods were applied to the morphological description of bone foramen in bone tissue sections,and the fractal similarity,anisotropy,and multipolar structural symmetry of bone foramen morphology were evaluated by box dimension counting method,deformation gradient tensor and Minkowski tensor,and the morphological tensor matrix was used to provide a unified morphological description standard for the morphology of bone hole morphology in slices,so as to develop the theoretical description of bone tissue section morphology by multiple mathematical methods.Taking the bionic bone tissue scaffold as the research object,the 3D solid printing of the scaffold was carried out,and its mechanical properties and flow field analysis were carried out,and the relationship between the effective Young’s modulus of the scaffold and the average pore size of the scaffold was studied,as well as the simulation analysis of the flow field velocity vector distribution of human body fluids in the scaffold and the shear stress distribution on the wall,so as to study whether the bone tissue scaffold can successfully complete the flow of body fluid and the growth of cells inside the scaffold after implantation in the human body,so as to obtain the effective repair of the bone in the defect site.