Correlation Between C-reactive Protein/Albumin Ratio,Myeloperoxidase And Coronary Heart Disease With Type 2 Diabetes

Objective:To explore the changes and significance of C-reactive protein/albumin ratio and myeloperoxidase in patients with coronary heart disease and type 2 diabetes.Methods:The subjects included in the study were 604 inpatients in the Cardiovascular Department of the Third Hospital of Shanxi Medical University from January 2021 to May 2022,including the simple coronary heart disease group(CAD group,n=151),type 2 diabetes group(T2DM group,n=150),coronary heart disease with type 2 diabetes group(T2DM+CAD group,n=151),and 152 non coronary heart disease and non diabetes patients as the control group(control group,n=152).Collect the general clinical and serological indicators of patients,and analyze the changes and significance of C-reactive protein/albumin ratio and myeloperoxidase in each group.Result:1.Compared with the other three groups,the levels of myeloperoxidase and C-reactive protein/albumin in the CAD+T2DM group were significantly higher(P<0.05);Compared with the control group,the levels of myeloperoxidase and C-reactive protein/albumin in the CAD group and T2 DM group were higher(P<0.05).2.In the CAD+T2DM group and T2 DM group,age,body mass index,total cholesterol,triglycerides,high-density lipoprotein cholesterol,low-density lipoprotein cholesterol,myeloperoxidase,and C-reactive protein/albumin ratio were used as dependent variables for one-way logistic regression.The results showed that myeloperoxidase,C-reactive protein/albumin ratio Low density lipoprotein cholesterol was a risk factor for coronary heart disease with type 2 diabetes,and the difference was statistically significant(P<0.05).3.The C-reactive protein/albumin ratio was significantly positively correlated with myeloperoxidase levels,while the C-reactive protein/albumin ratio and myeloperoxidase levels were significantly correlated in the CAD+T2DM group,the control group,the CAD group,and the T2 DM group(P<0.05).4.The ROC curve shows that the area under the curve(AUC)of CAR diagnosis of coronary heart disease with type 2 diabetes is 0.864 [95% CI(0.822,0.906)],the maximum cutoff value is 0.55,the sensitivity is 0.9474,and the specificity is 0.6026;The area under the curve(AUC)of MPO in diagnosing coronary heart disease with type 2diabetes was 0.994 [95% CI(0.986,1.000)],the maximum cut-off value was 0.9404,the sensitivity was 0.9868,and the specificity was 0.9536.Conclusion:1.C-reactive protein/albumin ratio and myeloperoxidase level were significantly correlated with the severity of coronary heart disease and type 2 diabetes.2.Elevated C-reactive protein/albumin ratio and myeloperoxidase level are risk factors for coronary heart disease with type 2 diabetes.3.C-reactive protein/albumin ratio and myeloperoxidase have certain predictive value for the auxiliary diagnosis of coronary heart disease with type 2 diabetes.