Characteristics Of Etiological Composition Ratio And Complications In 1279 Patients With Liver Cirrhosis

Objective:To explore the characteristics of etiology and complications in patients with liver cirrhosis,and to provide some evidence for clinical prevention and treatment.Methods:The medical records of patients with liver cirrhosis who were first hospitalized in the Third Hospital of Shanxi Medical University from January 1,2014 to December 31,2022 were retrospectively analyzed,mainly including gender,age,etiology,complications,etc.The etiology of liver cirrhosis,the proportion of complications,and the gender distribution and average age changes of patients with liver cirrhosis of different causes were compared.Results:1.General data analysis:Among the 1279 cirrhotic patients,792(61.92%)were male and 487(38.08%)were female,the male to female ratio was 1.63:1,and the mean age was(56.77±12.69)years.2.Composition of cirrhosis etiology:472 patients(36.90%)with hepatitis B cirrhosis,70 patients(5.47%)with hepatitis C cirrhosis,5 patients(0.39%)with hepatitis B plus hepatitis C cirrhosis,226 patients(17.67%)with alcoholic cirrhosis,61 patients(4.77%)with hepatitis B plus alcoholic cirrhosis,219 patients(17.12%)with autoimmune cirrhosis,16 patients(1.25%)with drug-induced cirrhosis,Twenty seven patients(2.11%)had nonalcoholic liver disease cirrhosis,5(0.47%)had Budd Chiari syndrome cirrhosis,11(0.86%)had Wilson’s disease cirrhosis,and 166(12.98%)had occult cirrhosis.3.Analysis of cirrhosis etiological components and gender differences:Among them,hepatitis B cirrhosis,alcoholic cirrhosis and hepatitis B with alcoholic cirrhosis are mainly male,accounting for 70.76%,99.12%and 100%respectively.The difference is statistically significant(χ~2=24.79,P<0.001;χ~2=161.04,P<0.001;χ~2=39.39,P<0.001).At the same time,the majority of patients with autoimmune cirrhosis and occult cirrhosis were women,accounting for 83.56%and 58.43%,respectively,with a statistically significant difference(χ~2=231.86,P<0.001;χ~2=33.53,P<0.001).4.Analysis of cirrhosis etiology and age distribution:In addition,patients with hepatitis B,hepatitis C,alcoholic and hepatitis B with alcoholic cirrhosis were mainly concentrated in the 50-59 age group,accounting for 33.3%,32.9%,32.7%and 34.4%respectively,with a statistically significant difference(P<0.001).The patients with autoimmune cirrhosis and occult cirrhosis were mainly concentrated in the age group≥70 years old,accounting for 35.2%and 30.1%,respectively,with a statistically significant difference(P<0.001).And there are differences in age distribution among different etiologies(χ~2=299.97,P<0.05).5.Complications of cirrhosis:ascites,electrolyte imbalance,upper gastrointestinal bleeding,infection,portal thrombosis,hepatic encephalopathy,liver cancer,as well as hepatorenal syndrome in order of incidence.The incidence of primary liver cancer and portal vein thrombosis in patients with hepatitis B cirrhosis is higher than that in patients with alcoholic cirrhosis(χ~2=76.59,P<0.001;χ~2=12.58,P<0.001);The incidence of hepatic encephalopathy and electrolyte disorder in patients with alcoholic cirrhosis is higher than that in patients with hepatitis B cirrhosis(χ~2=17.52,P<0.001;χ~2=4.12,P<0.05).In addition,compared with patients with alcoholic cirrhosis alone,patients with hepatitis B and alcoholic cirrhosis have a higher incidence of primary liver cancer and portal vein thrombosis(χ~2=13.69,P<0.001;χ~2=4.65,P<0.05),at the same time,compared with patients with hepatitis B cirrhosis alone,patients with hepatitis B combined with alcoholic cirrhosis had a higher incidence of hepatic encephalopathy(χ~2=8.77,P<0.05).Conclusion:Hepatitis B remains the main cause of cirrhosis,at the same time alcoholic cirrhosis and autoimmune cirrhosis also account for a large proportion,in addition to nonalcoholic fatty liver disease also needs to be paid attention.The main complications were ascites,electrolyte imbalance,and upper gastrointestinal bleeding.Actively etiological prevention can effectively reduce the incidence of cirrhosis,while good etiological treatment and management of complications can effectively improve the quality of life and prognosis of patients.