| Objective:To investigate the expression of serum soluble growth stimulating expression gene 2(sST2)and myeloperoxidase(MPO)in patients with acute ST-segment elevation myocardial infarction(STEMI)and their predictive value for prognosis.Methods:Eighty patients with acute ST-segment elevation myocardial infarction(STEMI)admitted to Shanxi Baiqiuen Hospital from October 2020 to October 2021 were selected as the observation group and followed up for 1 year.The patients were divided into MACE group(n=24)and non-MACE group(n=56)according to whether major adverse cardiovascular events(MACEs)occurred during the follow-up period.Another 67 patients with negative coronary angiography in our hospital during the same period were selected as the control group.The clinical data of all subjects were collected,and the levels of sST2 and MPO among all groups were compared.Receiver operating characteristic(ROC)curve was used to analyze the predictive value of sST2,MPO and their combined detection for poor prognosis in STEMI patients after PCI,and Logistic regression analysis was used to explore the influencing factors of poor prognosis in STEMI patients.Results:(1)There were statistically significant differences in sST2 and MPO between the acute ST-segment elevation myocardial infarction group and the control group(P<0.05),and there were statistically significant differences in sST2 and MPO between the MACE group and the non-MACE group(P<0.05),and the levels of sST2 and MPO in the MACE group were higher than those in the non-MACE group.(2)Serum sST2 was positively correlated with BNP,LVEDd and LVESd(r=0.352,0.289 and 0.322,P<0.05),and negatively correlated with LVEF(r=-0.420,P<0.01).MPO was positively correlated with LVEDd(r=0.256,P<0.05),and negatively correlated with LVEF(r=-0.220,P<0.05).(3)Serum sST2 was positively correlated with Myo and c Tn I(r=0.240,0.268,P<0.05),but not with CK-MB(P > 0.05).MPO was positively correlated with c Tn I(r =0.222,P<0.05),but not with CK-MB and Myo(P>0.05).(4)Serum sST2 and MPO were not related to the site of myocardial infarction;The difference of serum sST2 level in myocardial infarction area was statistically significant(P<0.05),the serum sST2 level in large myocardial infarction group was higher than that in small myocardial infarction group,and the serum MPO level was not statistically significant in myocardial infarction area(P>0.05).(5)sST2 and MPO were independent risk factors for poor prognosis in STEMI patients(P<0.05),and the combined detection of SST2 and MPO had the highest value in predicting MACE(ROC area: 0.832,sensitivity: 66.7%,specificity: 91.1%).Conclusion:1.The levels of sST2 and MPO in MACE group were higher than those in non-MACE group.sST2 is associated with cardiac function indexes(BNP,LVEDd,LVESd and LVEF),and can be used as a biomarker to predict cardiac dysfunction in STEMI patients after PCI.2.sST2 and MPO were not related to the location of myocardial infarction.3.sST2 and MPO are independent risk factors for poor prognosis in STEMI patients,and the combined detection of sST2 and MPO can provide better predictive value for the occurrence of MACE in STEMI patients within 1 year after PCI. |
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