Effects Of GnRH-a Supplementation As Luteal Support In GnRh Antagonist Cycles On Pregnancy Outcome

Objective:To investigate the effect of adding a short-acting gonadotropin-releasing hormone agonist(GnRH-a)as luteal phase support(LPS)in GnRH antagonist cycles on pregnancy outcome.Methods:A total of 356 cycles of IVF-ET/ICSI clinical data were included in the reproductive Center of our hospital from January 2021 to January 2022.This study was randomly divided into control group and experimental group according to different luteal protocols,with the control group being the conventional luteal phase support protocol for 187 cycles and the experimental group being the addition of short-acting GnRH-a on both transplantation day and on top the 3rd and 6th day after transplantation of conventional luteal phase support for 169 cycles.The clinical data,laboratory and clinical indicators of the two groups were compared respectively.Results:The differences were not statistically significant(P>0.05)when comparing the clinical data,ovulation promotion and embryos in the experimental and control groups.The number of transplants and embryo implantation rate was higher in the experimental group compared with the control group,and the difference was statistically significant(P<0.05).In addition,there were no significant differences between the two groups in clinical pregnancy rate,biochemical pregnancy rate,miscarriage rate,multiple pregnancy rate,and live birth rate(P>0.05).Logistic regression analysis:1.Age(OR=0.576,P=0.043),endometrial thickness of HCG day(OR=1.096,P=0.049)and the number of transplants(OR=1.710,P=0.029)had significant effects on the success of embryo implantation(P<0.05).The addition of GnRH-a in luteal phase support(OR=1.482,P=0.005)was an independent protective factor for the success of embryo implantation(P <0.05).2.Age(OR=0.542,P=0.028)was an independent risk factor in clinical pregnancy(P<0.05).The addition of GnRH-a in luteal phase support(OR=1.007,P=0.705)was not an independent factor in clinical pregnancy(P>0.05).Conclusion:1.For patients with GnRH-ant protocol,the addition of GnRH-a in luteal phase support can improve the embryo implantation rate.Age is an independent risk factor for the success of embryo implantation,and the increase of endometrial on HCG day and the number of transplants are independent protective factors for the success of embryo implantation.2.Age is an independent risk factor in clinical pregnancy.The addition of GnRH-a in luteal phase support has no significant effect on the clinical pregnancy rate.